A technological solution for the management of diabetes in people who require intensive
insulin therapy has been sought for decades. The last 10 years have seen substantial …

Overview IL-7 is a member of the family of cytokines with four anti-parallel α helixes that bind
Type I cytokine receptors. It is produced by stromal cells and is required for development …

We analyzed the effects of a single 14-day course of teplizumab treatment on metabolic
function and immune cells among participants in a previously reported randomized …

Affinity-based proteomics has enabled scalable quantification of thousands of protein targets
in blood enhancing biomarker discovery, understanding of disease mechanisms, and …

Biologic drugs have transformed the standard of care for many diseases. However, many
biologics induce the formation of anti-drug antibodies (ADAs), which can compromise their …

Thymic Stromal Lymphopoietin (TSLP) and Interleukin-7 (IL-7) are widely studied cytokines
within distinct branches of immunology. On one hand, TSLP is crucially important for …

The common γ chain (γc; IL-2RG) is a subunit of the interleukin (IL) receptors for the γc
cytokines IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. The lack of appropriate neutralizing …

Regulatory T cells (Tregs) have become highly relevant in the pathophysiology and
treatment of autoimmune diseases, such as type 1 diabetes (T1D). As these cells are known …

OSE-127 is a humanized mAb targeting the IL-7Rα-chain (CD127), under development for
inflammatory and autoimmune disease treatment. It is a strict antagonist of the IL-7R …

Introduction Despite the improvements of insulin therapy, people with type 1 diabetes (T1D)
still suffer from a decreased quality of life and life expectancy. The search toward a cure for …