Efflux pump mediated antimicrobial resistance by staphylococci in health-related environments: challenges and the quest for inhibition

A Dashtbani-Roozbehani, MH Brown - Antibiotics, 2021 - mdpi.com
The increasing emergence of antimicrobial resistance in staphylococcal bacteria is a major
health threat worldwide due to significant morbidity and mortality resulting from their …

[HTML][HTML] Combatting resistance: understanding multi-drug resistant pathogens in intensive care units

J Teng, S Imani, A Zhou, Y Zhao, L Du, S Deng… - Biomedicine & …, 2023 - Elsevier
The escalating misuse and excessive utilization of antibiotics have led to the widespread
dissemination of drug-resistant bacteria, posing a significant global healthcare crisis. Of …

Research progress on the synthesis and pharmacology of 1, 3, 4-oxadiazole and 1, 2, 4-oxadiazole derivatives: a mini review

JJ Wang, W Sun, WD Jia, M Bian… - Journal of Enzyme …, 2022 - Taylor & Francis
Oxadiazole is a five-membered heterocyclic compound containing two nitrogen atoms and
one oxygen atom. The 1, 3, 4-oxadiazole and 1, 2, 4-oxadiazole have favourable physical …

Tackling multidrug-resistant Staphylococcus aureus by natural products and their analogues acting as NorA efflux pump inhibitors

G Kumar, AK Tudu - Bioorganic & Medicinal Chemistry, 2023 - Elsevier
Staphylococcus aureus (S. aureus) is a pathogen responsible for various community and
hospital-acquired infections with life-threatening complications like bacteraemia …

A comprehensive review on genomics, systems biology and structural biology approaches for combating antimicrobial resistance in ESKAPE pathogens …

P Priyamvada, R Debroy, A Anbarasu… - World Journal of …, 2022 - Springer
In recent decades, antimicrobial resistance has been augmented as a global concern to
public health owing to the global spread of multidrug-resistant strains from different ESKAPE …

Bacterial Efflux Pump Inhibitors Reduce Antibiotic Resistance

L Zhang, X Tian, L Sun, K Mi, R Wang, F Gong… - Pharmaceutics, 2024 - mdpi.com
Bacterial resistance is a growing problem worldwide, and the number of deaths due to drug
resistance is increasing every year. We must pay great attention to bacterial resistance …

1, 2, 3-Triazole tethered hybrid capsaicinoids as antiproliferative agents active against lung cancer cells (A549)

A Khan, F Naaz, R Basit, D Das, P Bisht, M Shaikh… - ACS …, 2022 - ACS Publications
A series of novel 1, 2, 3-triazole derivatives of capsaicin and its structural isomer (new
natural product hybrid capsaicinoid) were synthesized by exploiting one-/two-point …

Synthesis and biological evaluation of capsaicin analogues as antioxidant and neuroprotective agents

M Xie, H Wu, J Bian, S Huang, Y Xia, Y Qin, Z Yan - RSC advances, 2023 - pubs.rsc.org
Capsaicin and its analogues 3a–3q were designed and synthesized as potential new
antioxidant and neuroprotective agents. Many analogues exhibited good antioxidant effects …

Photosensitizer associated with efflux pump inhibitors as a strategy for Photodynamic Therapy against bacterial resistance

IV da Cunha, DD da Silva Oliveira, GG Calefi… - European Journal of …, 2024 - Elsevier
Antimicrobial resistance is currently one of the biggest challenges in controlling infectious
diseases and was listed among the top 10 threats to global health by the World Health …

[HTML][HTML] Staphylococcus aureus antimicrobial efflux pumps and their inhibitors: recent developments

M Lekshmi, J Stephen, M Ojha, S Kumar… - AIMS Medical …, 2022 - aimspress.com
The microorganism Staphylococcus aureus is a notorious causative agent of bacterial
infection. The widespread presence of this pathogen has caused significant morbidity and …