According to the endosymbiotic theory, most of the DNA of the original bacterial
endosymbiont has been lost or transferred to the nucleus, leaving a much smaller (∼ 16 kb …

Aging induces a series of immune related changes, which is called immunosenescence,
playing important roles in many age-related diseases, especially neurodegenerative …

Mitochondrial DNA (mtDNA)—which is well known for its role in oxidative phosphorylation
and maternally inherited mitochondrial diseases—is increasingly recognized as an agonist …

Over the past millennia, life expectancy has drastically increased. While a mere 25 years
during Bronze and Iron ages, life expectancy in many European countries and in Japan is …

Aging is a complex phenomenon leading to numerous changes in the physiological systems
of the body. One of the most important changes, called immunosenescence, occurs in the …

Elderly asthmatics are at a higher risk for morbidity and mortality from their asthma than
younger patients. There are important age‐related physiologic and immunologic changes …

Aging of the immune system in humans and animals is characterized by a decline in both
adaptive and innate immune responses. Paradoxically, aging is also associated with a state …

Mitochondrial DNA (mtDNA) has many similarities with bacterial DNA because of their
shared common ancestry. Increasing evidence demonstrates mtDNA to be a potent danger …

Aging is characterized by the progressive decline of physiological function and tissue
homeostasis leading to increased vulnerability, degeneration, and death. Aging‐related …

Background Many drugs approved for other indications can control the growth of tumor cells
and limit adverse events (AE). Data sources Literature searches with keywords 'repurposing …