Mutations of Lamin A/C gene (LMNA) cause laminopathies, a group of disorders associated
with a wide spectrum of clinically distinct phenotypes, affecting different tissues and organs …

Mutations in RNA binding motif protein 20 (RBM20) are a common cause of familial dilated
cardiomyopathy (DCM). Many RBM20 mutations cluster within an arginine/serine-rich (RS …

Abstract Purpose of Review This review aims to give an update on recent findings related to
the cardiac splicing factor RNA-binding motif protein 20 (RBM20) and RBM20 …

Severe forms of dilated cardiomyopathy (DCM) are associated with point mutations in the
alternative splicing regulator RBM20 that are frequently located in the arginine/serine-rich …

Splice regulators play an essential role in the transcriptomic diversity of all eukaryotic cell
types and organ systems. Recent evidence suggests a contribution of splice-regulatory …

The identification of the molecular causes and subsequent insight into the molecular
mechanisms of DCM is expanding our understanding of DCM pathogenesis and highlights …

RBM20 is a vertebrate-specific RNA-binding protein with two zinc finger (ZnF) domains, one
RNA-recognition motif (RRM)-type RNA-binding domain and an arginine/serine (RS)-rich …

Alternative splicing is a regulatory mechanism essential for cell differentiation and tissue
organization. More than 90% of human genes are regulated by alternative splicing events …

Dilated cardiomyopathy (DCM) refers to a spectrum of heterogeneous myocardial disorders
characterized by ventricular dilation and depressed myocardial performance in the absence …

Introduction Dilated cardiomyopathy (DCM) is characterized by the dilation and impaired
contraction of 1 or both ventricles and can be caused by a variety of disorders. Up to 50% of …