The ability of cells to sense and respond to changes in mechanical environment is vital in
conditions of organ injury when the architecture of normal tissues is disturbed or lost. Among …

Integrin receptors are the main molecular link between cells and the extracellular matrix
(ECM) as well as mediating cell–cell interactions. Integrin–ECM binding triggers the …

The stiffness of the extracellular matrix induces differential tension within integrin-based
adhesions, triggering differential mechanoresponses. However, it has been unclear if the …

Objective Endocytosis is a process vital to angiogenesis and vascular homeostasis. In
pathologies where supraphysiological growth factor signaling underlies disease etiology …

In the system of magnesium‐loaded scaffolds, the effect of magnesium ions (Mg2+) on the
osteogenesis induction is restricted due to the low transmembrane transport efficiency of …

Integrin αIIbβ3 expresses on the plasma membrane of platelets, which can be activated by
mechanical pulling force from its ligand. Herein, we performed all-atom molecular dynamics …

Background Given the key role of integrins in maintaining intestinal homeostasis, anti-
integrin biologics in inflammatory bowel disease (IBD) are being investigated in full swing …

Cell adhesion and migration depend on the assembly and disassembly of adhesive
structures known as focal adhesions. Cells adhere to the extracellular matrix (ECM) and …

Integrins are heterodimeric cell-surface receptors that regulate cell–cell adhesion and
cellular functions through bidirectional signaling. On the other hand, anomalous trafficking of …

Scar formation during normal tissue regeneration in adults may result in noticeable cosmetic
and functional defects and have a significant impact on the quality of life. In contrast, fetal …