Over 1.66 million humans (approx. 500/100 000 population rate) and over 4.2 million dogs
(approx. 5300/100 000 population rate) are diagnosed with cancer annually in the USA. The …

Cancer is a common problem in dogs and although all breeds of dog and crossbred dogs
may be affected, it is notable that some breeds of pedigree dogs appear to be at increased …

Domestic dog breeds are characterized by an unrivaled diversity of morphologic traits and
breed-associated behaviors resulting from human selective pressures. To identify the …

Histiocytic proliferative disorders are commonly observed in dogs and less often cats.
Histiocytic disorders occur in most of the dendritic cell (DC) lineages. Canine cutaneous …

The domestic dog represents one of the most dramatic long-term evolutionary experiments
undertaken by humans. From a large wolf-like progenitor, unparalleled diversity in …

Spontaneous cancers in client-owned dogs closely recapitulate their human counterparts
with respect to clinical presentation, histological features, molecular profiles, and response …

Cancer is a disease of multicellularity; it originates when cells become dysregulated due to
mutations and grow out of control, invading other tissues and provoking discomfort …

Background Canine osteosarcoma is clinically nearly identical to the human disease, but is
common and highly heritable, making genetic dissection feasible. Results Through genome …

Spontaneously occurring melanomas are frequent in dogs. They appear at the same
localizations as in humans, ie skin, mucosal sites, nail matrix and eyes. They display …

Domestic dogs are unique from other animal models of cancer in that they generally
experience spontaneous disease. In addition, most types of cancer observed in humans are …