Nrf2 for protection against oxidant generation and mitochondrial damage in cardiac injury

QM Chen - Free Radical Biology and Medicine, 2022 - Elsevier
Myocardial infarction is the most common form of acute coronary syndrome. Blockage of a
coronary artery due to blood clotting leads to ischemia and subsequent cell death in the form …

[HTML][HTML] Innate-adaptive immunity interplay and redox regulation in immune response

L Sun, X Wang, J Saredy, Z Yuan, X Yang, H Wang - Redox biology, 2020 - Elsevier
Innate and adaptive immune cell activation and infiltration is the key characteristic of tissue
inflammation. The innate immune system is the front line of host defense in which innate …

MAFG-driven astrocytes promote CNS inflammation

MA Wheeler, IC Clark, EC Tjon, Z Li, SEJ Zandee… - Nature, 2020 - nature.com
Multiple sclerosis is a chronic inflammatory disease of the CNS. Astrocytes contribute to the
pathogenesis of multiple sclerosis, but little is known about the heterogeneity of astrocytes …

New insights into the role of mitochondria in cardiac microvascular ischemia/reperfusion injury

J Wang, S Toan, H Zhou - Angiogenesis, 2020 - Springer
As reperfusion therapies have become more widely used in acute myocardial infarction
patients, ischemia-induced myocardial damage has been markedly reduced, but reperfusion …

Oxidative stress and NRF2/KEAP1/ARE pathway in diabetic kidney disease (DKD): new perspectives

DM Tanase, EM Gosav, MI Anton, M Floria… - Biomolecules, 2022 - mdpi.com
Diabetes mellitus (DM) is one of the most debilitating chronic diseases worldwide, with
increased prevalence and incidence. In addition to its macrovascular damage, through its …

Nrf2 and oxidative stress in liver ischemia/reperfusion injury

R G. Bardallo, A Panisello‐Roselló… - The FEBS …, 2022 - Wiley Online Library
In response to stress signal, nuclear factor‐erythroid 2‐related factor 2 (Nrf2) induces the
expression of target genes involved in antioxidant defense and detoxification. Nrf2 activity is …

Hepatotoxic potentials of methotrexate: Understanding the possible toxicological molecular mechanisms

D Ezhilarasan - Toxicology, 2021 - Elsevier
Methotrexate (MTX) is one of the most effective and widely used drugs in the management of
autoimmune and dermatological diseases. Rheumatoid arthritis and psoriasis patients who …

Food protein-derived antioxidant peptides: Molecular mechanism, stability and bioavailability

Y Zhu, F Lao, X Pan, J Wu - Biomolecules, 2022 - mdpi.com
The antioxidant activity of protein-derived peptides was one of the first to be revealed among
the more than 50 known peptide bioactivities to date. The exploitation value associated with …

Arbutin as a skin depigmenting agent with antimelanogenic and antioxidant properties

YC Boo - Antioxidants, 2021 - mdpi.com
Arbutin is a compound of hydroquinone and D-glucose, and it has been over 30 years since
there have been serious studies on the skin lightening action of this substance. In the …

[HTML][HTML] Mitochondria in cancer

D Grasso, LX Zampieri, T Capelôa, JA Van de Velde… - Cell stress, 2020 - ncbi.nlm.nih.gov
The rediscovery and reinterpretation of the Warburg effect in the year 2000 occulted for
almost a decade the key functions exerted by mitochondria in cancer cells. Until recent …