Role of the transcription factor FOSL1 in organ development and tumorigenesis
VV Sobolev, AZ Khashukoeva, OE Evina… - International journal of …, 2022 - mdpi.com
The transcription factor FOSL1 plays an important role in cell differentiation and
tumorigenesis. Primarily, FOSL1 is crucial for the differentiation of several cell lineages …
tumorigenesis. Primarily, FOSL1 is crucial for the differentiation of several cell lineages …
[HTML][HTML] The transcription factor Fosl1 preserves Klotho expression and protects from acute kidney injury
L Cuarental, M Ribagorda, MI Ceballos… - Kidney International, 2023 - Elsevier
Increased expression of AP-1 transcription factor components has been reported in acute
kidney injury (AKI). However, the role of specific components, such as Fosl1, in tubular cells …
kidney injury (AKI). However, the role of specific components, such as Fosl1, in tubular cells …
TFAP2 paralogs facilitate chromatin access for MITF at pigmentation and cell proliferation genes
C Kenny, R Dilshat, HE Seberg, E Van Otterloo… - PLoS …, 2022 - journals.plos.org
In developing melanocytes and in melanoma cells, multiple paralogs of the Activating-
enhancer-binding Protein 2 family of transcription factors (TFAP2) contribute to expression of …
enhancer-binding Protein 2 family of transcription factors (TFAP2) contribute to expression of …
Activation of MAP2K signaling by genetic engineering or HF-rTMS promotes corticospinal axon sprouting and functional regeneration
Facilitating axon regeneration in the injured central nervous system remains a challenging
task. RAF-MAP2K signaling plays a key role in axon elongation during nervous system …
task. RAF-MAP2K signaling plays a key role in axon elongation during nervous system …
Integrating High-Throughput Approaches and in vitro Human Trophoblast Models to Decipher Mechanisms Underlying Early Human Placenta Development
The placenta is a temporary but pivotal organ for human pregnancy. It consists of multiple
specialized trophoblast cell types originating from the trophectoderm of the blastocyst stage …
specialized trophoblast cell types originating from the trophectoderm of the blastocyst stage …
Fosl1 is vital to heart regeneration upon apex resection in adult Xenopus tropicalis
HY Wu, YM Zhou, ZQ Liao, JW Zhong, YB Liu… - NPJ Regenerative …, 2021 - nature.com
Cardiovascular disease is the leading cause of death in the world due to losing regenerative
capacity in the adult heart. Frogs possess remarkable capacities to regenerate multiple …
capacity in the adult heart. Frogs possess remarkable capacities to regenerate multiple …
The global gene expression outline of the bovine blastocyst: reflector of environmental conditions and predictor of developmental capacity
D Salilew-Wondim, D Tesfaye, F Rings, E Held-Hoelker… - BMC genomics, 2021 - Springer
Background Morphological evaluation of embryos has been used to screen embryos for
transfer. However, the repeatability and accuracy of this method remains low. Thus …
transfer. However, the repeatability and accuracy of this method remains low. Thus …
Systematic mapping of TF-mediated cell fate changes by a pooled induction coupled with scRNA-seq and multi-omics approaches
Transcriptional regulation controls cellular functions through interactions between
transcription factors (TFs) and their chromosomal targets. However, understanding the fate …
transcription factors (TFs) and their chromosomal targets. However, understanding the fate …
ATG7-mediated autophagy facilitates embryonic stem cell exit from naive pluripotency and marks commitment to differentiation
J Zhou, H He, JJ Zhang, X Liu, W Yao, C Li, T Xu… - Autophagy, 2022 - Taylor & Francis
Macroautophagy/autophagy is a conserved cellular mechanism to degrade unneeded
cytoplasmic proteins and organelles to recycle their components, and it is critical for …
cytoplasmic proteins and organelles to recycle their components, and it is critical for …
FOSL1 promotes stem cell-like characteristics and anoikis resistance to facilitate tumorigenesis and metastasis in osteosarcoma by targeting SOX2
Y Wang, Q Hu, Y Cao, L Yao, H Liu… - International …, 2024 - spandidos-publications.com
Metastasis is the leading cause of cancer-related death in osteosarcoma (OS). OS stem cells
(OSCs) and anoikis resistance are considered to be essential for tumor metastasis …
(OSCs) and anoikis resistance are considered to be essential for tumor metastasis …