Targeting the progression of chronic kidney disease
Chronic kidney disease (CKD) is a devastating condition that is reaching epidemic levels
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …
[HTML][HTML] Antioxidant responses and cellular adjustments to oxidative stress
C Espinosa-Diez, V Miguel, D Mennerich, T Kietzmann… - Redox biology, 2015 - Elsevier
Redox biological reactions are now accepted to bear the Janus faceted feature of promoting
both physiological signaling responses and pathophysiological cues. Endogenous …
both physiological signaling responses and pathophysiological cues. Endogenous …
The biochemistry and effectiveness of antioxidants in food, fruits, and marine algae
It is more effective to maintain good health than to regain it after losing it. This work focuses
on the biochemical defense mechanisms against free radicals and their role in building and …
on the biochemical defense mechanisms against free radicals and their role in building and …
[HTML][HTML] European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)
Abstract The European Cooperation in Science and Technology (COST) provides an ideal
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …
Reactive oxygen species and fibrosis: further evidence of a significant liaison
K Richter, T Kietzmann - Cell and tissue research, 2016 - Springer
Age-related diseases such as obesity, diabetes, non-alcoholic fatty liver disease, chronic
kidney disease and cardiomyopathy are frequently associated with fibrosis. Work within the …
kidney disease and cardiomyopathy are frequently associated with fibrosis. Work within the …
TrxR1 as a potent regulator of the Nrf2-Keap1 response system
M Cebula, EE Schmidt, ESJ Arnér - Antioxidants & redox signaling, 2015 - liebertpub.com
Significance: All cells must maintain a balance between oxidants and reductants, while
allowing for fluctuations in redox states triggered by signaling, altered metabolic flow, or …
allowing for fluctuations in redox states triggered by signaling, altered metabolic flow, or …
MicroRNA networks modulate oxidative stress in cancer
YH Lin - International journal of molecular sciences, 2019 - mdpi.com
Imbalanced regulation of reactive oxygen species (ROS) and antioxidant factors in cells is
known as “oxidative stress (OS)”. OS regulates key cellular physiological responses through …
known as “oxidative stress (OS)”. OS regulates key cellular physiological responses through …
[HTML][HTML] Crucial role of miR-433 in regulating cardiac fibrosis
Dysregulation of microRNAs has been implicated in many cardiovascular diseases
including fibrosis. Here we report that miR-433 was consistently elevated in three models of …
including fibrosis. Here we report that miR-433 was consistently elevated in three models of …
[HTML][HTML] Redox regulation of genome stability by effects on gene expression, epigenetic pathways and DNA damage/repair
Reactive oxygen and nitrogen species (eg H 2 O 2, nitric oxide) confer redox regulation of
essential cellular signaling pathways such as cell differentiation, proliferation, migration and …
essential cellular signaling pathways such as cell differentiation, proliferation, migration and …
Natural compounds and glutathione: Beyond mere antioxidants
The tripeptide glutathione plays important roles in many cell processes, including
differentiation, proliferation, and apoptosis; in fact, disorders in glutathione homeostasis are …
differentiation, proliferation, and apoptosis; in fact, disorders in glutathione homeostasis are …