Cell shape and forces in elastic and structured environments: from single cells to organoids

R Link, K Weißenbruch, M Tanaka… - Advanced Functional …, 2023 - Wiley Online Library
With the advent of mechanobiology, cell shape and forces have emerged as essential
elements of cell behavior and fate, in addition to biochemical factors such as growth factors …

Bioengineered skin organoids: from development to applications

ZX Hong, ST Zhu, H Li, JZ Luo, Y Yang, Y An… - Military Medical …, 2023 - Springer
Significant advancements have been made in recent years in the development of highly
sophisticated skin organoids. Serving as three-dimensional models that mimic human skin …

Varying mechanical forces drive sensory epithelium formation

M Xia, M Wu, Y Li, Y Liu, G Jia, Y Lou, J Ma, Q Gao… - Science …, 2023 - science.org
The mechanical cues of the external microenvironment have been recognized as essential
clues driving cell behavior. Although intracellular signals modulating cell fate during sensory …

Advancements in inner ear development, regeneration, and repair through otic organoids

C Nist-Lund, J Kim, KR Koehler - Current opinion in genetics & …, 2022 - Elsevier
The vertebrate inner ear contains a diversity of unique cell types arranged in a particularly
complex 3D cytoarchitecture. Both of these features are integral to the proper development …

Apical expansion of calvarial osteoblasts and suture patency is dependent on fibronectin cues

X Feng, H Molteni, M Gregory, J Lanza… - …, 2024 - journals.biologists.com
The skull roof, or calvaria, is comprised of interlocking plates of bones that encase the brain.
Separating these bones are fibrous sutures that permit growth. Currently, we do not …

[HTML][HTML] Inner ear organoids: recent progress and potential applications

Y Lou, Y Liu, M Wu, G Jia, M Xia, W Li - Fundamental Research, 2023 - Elsevier
The inner ear is one of the most complicated structures that harbor organs for the perception
of sound and balance, which is deep in the temporal bone and challenging to operate …

Epithelial UNC-23 limits mechanical stress to maintain glia-neuron architecture in C. elegans

CG Martin, JS Bent, T Hill, I Topalidou, A Singhvi - Developmental Cell, 2024 - cell.com
For an organ to maintain correct architecture and function, its diverse cellular components
must coordinate their size and shape. Although cell-intrinsic mechanisms driving homotypic …

Epithelia delimits glial apical polarity against mechanical shear to maintain glia-neuron-architecture

CG Martin, JS Bent, A Singhvi - BioRxiv, 2022 - biorxiv.org
For an organ to maintain proper architecture and function, its different component cell-types
must coordinate their cell-shapes with each other through life. While cell-intrinsic …

Pioneer statoacoustic neurons guide neuroblast behaviour during otic ganglion assembly

A Bañón, B Alsina - Development, 2023 - journals.biologists.com
Cranial ganglia are aggregates of sensory neurons that mediate distinct types of sensation.
The statoacoustic ganglion (SAG) develops into several lobes that are spatially arranged to …

Pioneer statoacoustic neurons guide neuroblast behaviour during otic ganglion assembly

A Bañón González… - Development. 2023 Nov 1; …, 2023 - repositori.upf.edu
Cranial ganglia are aggregates of sensory neurons that mediate distinct types of sensation.
The statoacoustic ganglion (SAG) develops into several lobes that are spatially arranged to …