In the last two decades, Fourier Transform Infrared (FTIR) and Raman spectroscopies turn
out to be valuable tools, capable of providing fingerprint-type information on the composition …

It has long been axiomatic that a protein's structure determines its function. Intrinsically
disordered proteins (IDPs) and disordered protein regions (IDRs) defy this structure …

Infrared spectroscopy is an extremely important instrumental tool in applied and basic
sciences for the determination of various functional groups. In this chapter, we have …

The ability to obtain a molecular-level understanding of the chemistry that takes place at
liquid/solid interfaces is key to the development and improvement of many chemical and …

Structural studies of Alzheimer's amyloid fibrils have revealed information about the structure
at different levels. The amyloid-β peptide has been examined in various solvents and …

Protein misfolding and aggregation are the hallmark of a number of diseases including
Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral …

The presence of β‐sheets in the core of amyloid fibrils raised questions as to whether or not
β‐sheet‐containing proteins, such as transthyretin, are predisposed to form such fibrils …

Alzheimer's disease (AD) is characterized by the misfolding and plaque-like accumulation of
a naturally occurring peptide in the brain called amyloid beta (Aβ). Recently, this process …

Fourier transform infrared (FT-IR) imaging and microspectroscopy have been extensively
applied to the analyses of tissues in health and disease. Spatially resolved mid-IR data has …

Many neurodegenerative diseases are characterized by the accumulation of abnormal
protein aggregates in the brain. In Parkinson's disease (PD), α-synuclein (α-syn) forms such …