The metabolism of cancer cells during metastasis
G Bergers, SM Fendt - Nature Reviews Cancer, 2021 - nature.com
Metastasis formation is the major cause of death in most patients with cancer. Despite
extensive research, targeting metastatic seeding and colonization is still an unresolved …
extensive research, targeting metastatic seeding and colonization is still an unresolved …
The calcium–cancer signalling nexus
GR Monteith, N Prevarskaya… - Nature Reviews …, 2017 - nature.com
The calcium signal is a powerful and multifaceted tool by which cells can achieve specific
outcomes. Cellular machinery important in tumour progression is often driven or influenced …
outcomes. Cellular machinery important in tumour progression is often driven or influenced …
[HTML][HTML] Lipid-laden lung mesenchymal cells foster breast cancer metastasis via metabolic reprogramming of tumor cells and natural killer cells
While the distant organ environment is known to support metastasis of primary tumors, its
metabolic roles in this process remain underdetermined. Here, in breast cancer models, we …
metabolic roles in this process remain underdetermined. Here, in breast cancer models, we …
Metabolic reprogramming from glycolysis to fatty acid uptake and beta-oxidation in platinum-resistant cancer cells
Increased glycolysis is considered as a hallmark of cancer. Yet, cancer cell metabolic
reprograming during therapeutic resistance development is under-studied. Here, through …
reprograming during therapeutic resistance development is under-studied. Here, through …
Adipocyte-derived lipids mediate melanoma progression via FATP proteins
Advanced, metastatic melanomas frequently grow in subcutaneous tissues and portend a
poor prognosis. Though subcutaneous tissues are largely composed of adipocytes, the …
poor prognosis. Though subcutaneous tissues are largely composed of adipocytes, the …
[HTML][HTML] FTO-mediated autophagy promotes progression of clear cell renal cell carcinoma via regulating SIK2 mRNA stability
The progression of clear cell renal cell carcinoma (ccRCC) remains a major challenge in
clinical practice, and elucidation of the molecular drivers of malignancy progression is …
clinical practice, and elucidation of the molecular drivers of malignancy progression is …
An evolving story of the metastatic voyage of ovarian cancer cells: cellular and molecular orchestration of the adipose-rich metastatic microenvironment
T Motohara, K Masuda, M Morotti, Y Zheng… - Oncogene, 2019 - nature.com
Metastasis is a complex multistep process that involves critical interactions between cancer
cells and a variety of stromal components in the tumor microenvironment, which profoundly …
cells and a variety of stromal components in the tumor microenvironment, which profoundly …
The potent roles of salt-inducible kinases (SIKs) in metabolic homeostasis and tumorigenesis
Z Sun, Q Jiang, J Li, J Guo - Signal transduction and targeted therapy, 2020 - nature.com
Salt-inducible kinases (SIKs) belong to AMP-activated protein kinase (AMPK) family, and
functions mainly involve in regulating energy response-related physiological processes …
functions mainly involve in regulating energy response-related physiological processes …
Metabolic dependencies and targets in ovarian cancer
Reprogramming of cellular metabolism is a hallmark of cancer. Cancer cells undergo
metabolic adaptations to maintain tumorigenicity and survive under the attack of immune …
metabolic adaptations to maintain tumorigenicity and survive under the attack of immune …
[HTML][HTML] Calcium signaling and the therapeutic targeting of cancer cells
AHL Bong, GR Monteith - Biochimica et Biophysica Acta (BBA)-Molecular …, 2018 - Elsevier
The calcium signal is implicated in a variety of processes important in tumor progression (eg
proliferation and invasiveness). The calcium signal has also been shown to be important in …
proliferation and invasiveness). The calcium signal has also been shown to be important in …