The metabolism of cancer cells during metastasis

G Bergers, SM Fendt - Nature Reviews Cancer, 2021 - nature.com
Metastasis formation is the major cause of death in most patients with cancer. Despite
extensive research, targeting metastatic seeding and colonization is still an unresolved …

The calcium–cancer signalling nexus

GR Monteith, N Prevarskaya… - Nature Reviews …, 2017 - nature.com
The calcium signal is a powerful and multifaceted tool by which cells can achieve specific
outcomes. Cellular machinery important in tumour progression is often driven or influenced …

[HTML][HTML] Lipid-laden lung mesenchymal cells foster breast cancer metastasis via metabolic reprogramming of tumor cells and natural killer cells

Z Gong, Q Li, J Shi, ET Liu, LD Shultz, G Ren - Cell metabolism, 2022 - cell.com
While the distant organ environment is known to support metastasis of primary tumors, its
metabolic roles in this process remain underdetermined. Here, in breast cancer models, we …

Metabolic reprogramming from glycolysis to fatty acid uptake and beta-oxidation in platinum-resistant cancer cells

Y Tan, J Li, G Zhao, KC Huang, H Cardenas… - Nature …, 2022 - nature.com
Increased glycolysis is considered as a hallmark of cancer. Yet, cancer cell metabolic
reprograming during therapeutic resistance development is under-studied. Here, through …

Adipocyte-derived lipids mediate melanoma progression via FATP proteins

M Zhang, JS Di Martino, RL Bowman, NR Campbell… - Cancer discovery, 2018 - AACR
Advanced, metastatic melanomas frequently grow in subcutaneous tissues and portend a
poor prognosis. Though subcutaneous tissues are largely composed of adipocytes, the …

[HTML][HTML] FTO-mediated autophagy promotes progression of clear cell renal cell carcinoma via regulating SIK2 mRNA stability

Y Xu, J Zhou, L Li, W Yang, Z Zhang… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
The progression of clear cell renal cell carcinoma (ccRCC) remains a major challenge in
clinical practice, and elucidation of the molecular drivers of malignancy progression is …

An evolving story of the metastatic voyage of ovarian cancer cells: cellular and molecular orchestration of the adipose-rich metastatic microenvironment

T Motohara, K Masuda, M Morotti, Y Zheng… - Oncogene, 2019 - nature.com
Metastasis is a complex multistep process that involves critical interactions between cancer
cells and a variety of stromal components in the tumor microenvironment, which profoundly …

The potent roles of salt-inducible kinases (SIKs) in metabolic homeostasis and tumorigenesis

Z Sun, Q Jiang, J Li, J Guo - Signal transduction and targeted therapy, 2020 - nature.com
Salt-inducible kinases (SIKs) belong to AMP-activated protein kinase (AMPK) family, and
functions mainly involve in regulating energy response-related physiological processes …

Metabolic dependencies and targets in ovarian cancer

Y Zhang, Y Wang, G Zhao, S Orsulic, D Matei - Pharmacology & …, 2023 - Elsevier
Reprogramming of cellular metabolism is a hallmark of cancer. Cancer cells undergo
metabolic adaptations to maintain tumorigenicity and survive under the attack of immune …

[HTML][HTML] Calcium signaling and the therapeutic targeting of cancer cells

AHL Bong, GR Monteith - Biochimica et Biophysica Acta (BBA)-Molecular …, 2018 - Elsevier
The calcium signal is implicated in a variety of processes important in tumor progression (eg
proliferation and invasiveness). The calcium signal has also been shown to be important in …