Lysosomes are composed of soluble and transmembrane proteins that are targeted to
lysosomes in a signal-dependent manner. The majority of soluble acid hydrolases are …

Cathepsins were originally identified as proteases that act in the lysosome. Recent work has
uncovered nontraditional roles for cathepsins in the extracellular space as well as in the …

During the last decade, there have been enormous advances in our knowledge of
glycoproteins and the stage has been set for the biotechnological production of many of …

To automate examination of massive amounts of sequence data for biological function, it is
important to computerize interpretation based on empirical knowledge of sequence-function …

This review focuses on the pathways that regulate lysosome biogenesis and that are
implicated in numerous degenerative storage diseases, including lysosomal storage …

Lysosomal hydrolases are synthesized in the rough endoplasmic reticulum and specifically
transported through the Golgi apparatus to the trans-Golgi network, from which transport …

Staphylococcal protein A is anchored to the cell wall, a unique cellular compartment of Gram‐
positive bacteria. The sorting signal sufficient for cell wall anchoring consists of an LPXTG …

Background: Sulfatases catalyze the hydrolysis of sulfuric acid esters from a wide variety of
substrates including glycosaminoglycans, glycolipids and steroids. There is sufficient …

Cathepsin D (EC 3.4. 23.5) is a lysosomal protease suspected to play important roles in
protein catabolism, antigen processing, degenerative diseases, and breast cancer …

DESPITE its importance, the molecular basis of mammalian gamete recognition has
remained unclear. The enzyme β-1, 4-galactosyltransferase (Gal-transferase) has been …