Carbapenem resistance in gram-negative bacteria has caused a global epidemic that
continues to grow. Although carbapenemase-producing Enterobacteriaceae have received …

β-Lactams are the most widely used class of antibiotics. Since the discovery of
benzylpenicillin in the 1920s, thousands of new penicillin derivatives and related β-lactam …

Background: Previous evidence-based guidelines on the management of intra-abdominal
infection (IAI) were published by the Surgical Infection Society (SIS) in 1992, 2002, and …

Purpose This study aims to determine if continuous infusion (CI) is associated with better
clinical and pharmacokinetic/pharmacodynamic (PK/PD) outcomes compared to intermittent …

Metallo-β-lactamase-producing Pseudomonas aeruginosa (MPPA) is an important
nosocomial pathogen that shows resistance to all β-lactam antibiotics except monobactams …

Septicaemia likely results in high case-fatality rates in the present multidrug-resistant (MDR)
era. Amongst them are hospital-acquired pneumonia (HAP) and ventilator-associated …

Successful antibiotic therapy in the critically ill requires sufficient drug concentrations at the
site of infection that kill or suppress bacterial growth. The relationship between antibiotic …

Antibiotics discovery has always played an important role in curing several outpacing
resistances. Effective treatments for many of the common infectious diseases have now …

Background Antimicrobial resistance is a major contemporary public health threat.
Strategies to contain antimicrobial resistance have been comprehensively set forth, however …

Antimicrobial resistance has become one of the most serious public health concerns
worldwide. Although circumstances may vary by region or country, it is clear that some Asian …