The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …

The variety of physiological functions controlled by dopamine in the brain and periphery is
mediated by the D 1, D 2, D 3, D 4 and D 5 dopamine GPCRs. Drugs acting on dopamine …

Dopamine is involved in physiological processes like learning and memory, motor control
and reward, and pathological conditions such as Parkinson's disease and addiction. In …

Anxiety is an unpleasant physiological state in which an overreaction to a situation occurs. It
has been suggested that different brain regions are involved in the modulation and …

The prefrontal cortex (PFC) is a hub for cognitive control, and dopamine profoundly
influences its functions. In other brain regions, astrocytes sense diverse neurotransmitters …

Actions of the neurotransmitter dopamine in the brain are mediated by dopamine receptors
that belong to the superfamily of G protein-coupled receptors (GPCRs). Mammals have five …

Antipsychotic drugs targeting dopamine neurotransmission are still the principal mean of
therapeutic intervention for schizophrenia. However, about one third of people do not …

The ongoing epidemics of metabolic diseases and increase in the older population have
increased the incidences of neurodegenerative diseases. Evidence from murine and cell …

In animal models of Parkinson′ s disease, striatal overactivation of ERK1/2 via dopamine
(DA) D1 receptors is the hallmark of a supersensitive molecular response associated with …

Dopaminergic neurons in the ventral tegmental area, the major midbrain nucleus projecting
to the motor cortex, play a key role in motor skill learning and motor cortex synaptic plasticity …