Animal models of human diseases that accurately recapitulate clinical pathology are
indispensable for understanding molecular mechanisms and advancing preclinical studies …

Cerebral amyloid angiopathy (CAA) is an important cerebral small vessel disease
associated with brain haemorrhage and cognitive change. The commonest form, sporadic …

A number of studies have reported that aberrant expression of microRNAs (miRNAs) closely
correlates with the bone metastasis of prostate cancer (PCa). However, clinical significance …

Abstract Currently, 5.4 million Americans suffer from AD, and these numbers are expected to
increase up to 16 million by 2050. Despite tremendous research efforts, we still do not have …

The abnormal regulation of amyloid-β (Aβ) metabolism (eg, production, cleavage,
clearance) plays a central role in Alzheimer's disease (AD). Among endogenous factors …

Circulating microRNAs (miRNAs) are emerging biomarkers for type 2 diabetes mellitus
(T2DM). However, a comprehensive characterization of the serum miRNA profile in patients …

Alzheimer's disease (AD), Parkinson's disease (PD), frontotemporal dementia (FTD),
amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), and prion diseases have a …

Aging is a normal process of living being. It has been reported that multiple cellular changes,
including oxidative damage/mitochondrial dysfunction, telomere shortening, inflammation …

Although APP metabolism is being intensively investigated, a large fraction of its modulators
is yet to be characterized. In this context, we combined two genome-wide high-content …

In this study, we have compared the severity of amyloid plaque formation and cerebral
amyloid angiopathy (CAA), and the subtype pattern of CAA pathology itself, between APP …