Epithelial ovarian cancer (EOC) remains the most lethal of all the gynaecological
malignancies with drug resistance and recurrence remaining the major therapeutic barrier in …

Recently, the existence of a mechanism for neo-oogenesis in the ovaries of adult mammals
has generated much controversy within reproductive biology. This mechanism, which …

Background In previous studies it has been found that in cell cultures of human adult ovaries
there is a population of small stem cells with diameters of 2–4 μm, which are present mainly …

Objective The objectives of this study were to assess cancer stem cell–related marker
NANOG expression in ovarian serous tumors and to evaluate its prognostic significance in …

Background It is well known that somatotrophic/insulin signaling affects lifespan in
experimental animals, and one of the signs of aging is progressive gonadal dysfunction …

It is a long held doctrine in reproductive biology that women are born with a finite number of
oocytes and there is no oogenesis during the postnatal period. However, recent evidence …

For decades, scientists have considered that female mammals are born with a lifetime
reserve of oocytes in the ovary, irrevocably fated to decline after birth. However, controversy …

Ovarian cancer is among the most common gynecologic cancers and unfortunately the most
common cause of death from gynecologic malignancies. Due to few early symptoms and …

Background Many studies have proposed that putative ovarian stem cells (OSCs) derived
from the ovarian surface epithelium (OSE) layer of adult mammalian ovaries can produce …

Summary Purpose of Investigation: The objective of the study was to evaluate cancer stem
cell-related marker NANOG expression in ovarian serous tumors using Western blotting …