Interlinked and fundamental aging processes appear to be a root-cause contributor to many
disorders and diseases. One such process is cellular senescence, which entails a state of …

Cellular senescence is a ubiquitous process with roles in tissue remodelling, including
wound repair and embryogenesis. However, prolonged senescence can be maladaptive …

Senescent cells drive age-related tissue dysfunction partially through the induction of a
chronic senescence-associated secretory phenotype (SASP). Mitochondria are major …

Ageing organisms accumulate senescent cells that are thought to contribute to body
dysfunction. Telomere shortening and damage are recognized causes of cellular …

Although cellular senescence drives multiple age-related co-morbidities through the
senescence-associated secretory phenotype, in vivo senescent cell identification remains …

Alzheimer's disease and related dementias (ADRD) are among the top contributors to
disability and mortality in later life. As with many chronic conditions, aging is the single most …

Senescent cells are highly associated with aging and pathological conditions and could be
targeted to slow the aging process. One commonly used marker to examine senescent cells …

Cellular senescence is a cell fate triggered in response to stress and is characterized by
stable cell-cycle arrest and a hypersecretory state. It has diverse biological roles, ranging …

Aging is the greatest risk factor for late-onset Alzheimer's disease (LOAD), which accounts
for> 95% of Alzheimer's disease (AD) cases. The mechanism underlying the aging-related …

Alzheimer's disease (AD) predominantly occurs as a late onset (LOAD) form involving
neurodegeneration and cognitive decline with progressive memory loss. Risk factors that …