The effects of type 2 diabetes mellitus on organ metabolism and the immune system
Metabolic abnormalities such as dyslipidemia, hyperinsulinemia, or insulin resistance and
obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM) …
obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM) …
A bittersweet response to infection in diabetes; targeting neutrophils to modify inflammation and improve host immunity
Chronic and recurrent infections occur commonly in both type 1 and type 2 diabetes (T1D,
T2D) and increase patient morbidity and mortality. Neutrophils are professional phagocytes …
T2D) and increase patient morbidity and mortality. Neutrophils are professional phagocytes …
Dysregulation of leukocyte trafficking in type 2 diabetes: mechanisms and potential therapeutic avenues
Type 2 Diabetes Mellitus (T2DM) is a chronic inflammatory disorder that is characterized by
chronic hyperglycemia and impaired insulin signaling which in addition to be caused by …
chronic hyperglycemia and impaired insulin signaling which in addition to be caused by …
[HTML][HTML] Glucose supply and glycolysis inhibition shape the clinical fate of Staphylococcus epidermidis–infected preterm newborns
Preterm infants are susceptible to bloodstream infection by coagulase-negative
staphylococci (CONS) that can lead to sepsis. Glucose-rich parenteral nutrition is commonly …
staphylococci (CONS) that can lead to sepsis. Glucose-rich parenteral nutrition is commonly …
Hyperglycemia impairs neutrophil mobilization leading to enhanced metastatic seeding
T Fainsod-Levi, M Gershkovitz, S Völs, S Kumar… - Cell reports, 2017 - cell.com
Preexisting diabetes is a risk factor for the development of multiple types of cancer.
Additionally, diabetic patients face a poorer prognosis when diagnosed with cancer. To gain …
Additionally, diabetic patients face a poorer prognosis when diagnosed with cancer. To gain …
Infection with the Lyme disease pathogen suppresses innate immunity in mice with diet‐induced obesity
N Zlotnikov, A Javid, M Ahmed, A Eshghi… - Cellular …, 2017 - Wiley Online Library
Obesity is a major global public health concern. Immune responses implicated in obesity
also control certain infections. We investigated the effects of high‐fat diet‐induced obesity …
also control certain infections. We investigated the effects of high‐fat diet‐induced obesity …
The Lyme disease spirochete can hijack the host immune system for extravasation from the microvasculature
X Tan, B Petri, R DeVinney, CN Jenne… - Molecular …, 2021 - Wiley Online Library
Lyme disease is the most common tick‐transmitted disease in the northern hemisphere and
is caused by the spirochete Borrelia burgdorferi and related Borrelia species. The …
is caused by the spirochete Borrelia burgdorferi and related Borrelia species. The …
Leishmania amazonensis infection regulates oxidate stress in hyperglycemia and diabetes impairing macrophage's function and immune response
Leishmaniasis is a group of infectious diseases caused by protozoa of the Leishmania
genus and its immunopathogenesis results from an unbalanced immune response during …
genus and its immunopathogenesis results from an unbalanced immune response during …
Characterization of Stress and Innate Immunity Resistance of Wild-Type and Δp66 Borrelia burgdorferi
Borrelia burgdorferi is a causative agent of Lyme disease, the most common arthropod-
borne disease in the United States. B. burgdorferi evades host immune defenses to …
borne disease in the United States. B. burgdorferi evades host immune defenses to …
The Lyme disease pathogen Borrelia burgdorferi infects murine bone and induces trabecular bone loss
TT Tang, L Zhang, A Bansal, M Grynpas… - Infection and …, 2017 - Am Soc Microbiol
Lyme disease is caused by members of the Borrelia burgdorferi sensu lato species complex.
Arthritis is a well-known late-stage pathology of Lyme disease, but the effects of B …
Arthritis is a well-known late-stage pathology of Lyme disease, but the effects of B …