[HTML][HTML] An overview of the main genetic, epigenetic and environmental factors involved in autism spectrum disorder focusing on synaptic activity

E Masini, E Loi, AF Vega-Benedetti, M Carta… - International journal of …, 2020 - mdpi.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that affects social
interaction and communication, with restricted interests, activity and behaviors. ASD is highly …

Common mechanisms of excitatory and inhibitory imbalance in schizophrenia and autism spectrum disorders

R Gao, P Penzes - Current molecular medicine, 2015 - ingentaconnect.com
Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with
complex genetic architectures but overlapping behavioral phenotypes, which suggests …

Revealing the structure of pharmacobehavioral space through motion sequencing

AB Wiltschko, T Tsukahara, A Zeine, R Anyoha… - Nature …, 2020 - nature.com
Understanding how genes, drugs and neural circuits influence behavior requires the ability
to effectively organize information about similarities and differences within complex …

A high-coverage genome sequence from an archaic Denisovan individual

M Meyer, M Kircher, MT Gansauge, H Li, F Racimo… - Science, 2012 - science.org
We present a DNA library preparation method that has allowed us to reconstruct a high-
coverage (30×) genome sequence of a Denisovan, an extinct relative of Neandertals. The …

Neuroimaging in autism spectrum disorder: brain structure and function across the lifespan

C Ecker, SY Bookheimer, DGM Murphy - The Lancet Neurology, 2015 - thelancet.com
Over the past decade, in-vivo MRI studies have provided many invaluable insights into the
neural substrates underlying autism spectrum disorder (ASD), which is now known to be …

Gene hunting in autism spectrum disorder: on the path to precision medicine

DH Geschwind - The Lancet Neurology, 2015 - thelancet.com
Autism spectrum disorder is typical of the majority of neuropsychiatric syndromes in that it is
defined by signs and symptoms, rather than by aetiology. Not surprisingly, the causes of this …

Disentangling the heterogeneity of autism spectrum disorder through genetic findings

SS Jeste, DH Geschwind - Nature Reviews Neurology, 2014 - nature.com
Autism spectrum disorder (ASD) represents a heterogeneous group of disorders, which
presents a substantial challenge to diagnosis and treatment. Over the past decade …

Interneuron dysfunction in psychiatric disorders

O Marín - Nature Reviews Neuroscience, 2012 - nature.com
Schizophrenia, autism and intellectual disabilities are best understood as spectrums of
diseases that have broad sets of causes. However, it is becoming evident that these …

Transcriptomic analysis of autistic brain reveals convergent molecular pathology

I Voineagu, X Wang, P Johnston, JK Lowe, Y Tian… - Nature, 2011 - nature.com
Autism spectrum disorder (ASD) is a common, highly heritable neurodevelopmental
condition characterized by marked genetic heterogeneity,,. Thus, a fundamental question is …

[HTML][HTML] Autism-associated neuroligin-3 mutations commonly impair striatal circuits to boost repetitive behaviors

PE Rothwell, MV Fuccillo, S Maxeiner, SJ Hayton… - Cell, 2014 - cell.com
In humans, neuroligin-3 mutations are associated with autism, whereas in mice, the
corresponding mutations produce robust synaptic and behavioral changes. However …