Structurally dynamic hydrogels for biomedical applications: pursuing a fine balance between macroscopic stability and microscopic dynamics
Owing to their unique chemical and physical properties, hydrogels are attracting increasing
attention in both basic and translational biomedical studies. Although the classical hydrogels …
attention in both basic and translational biomedical studies. Although the classical hydrogels …
Molecular mechanisms of exercise contributing to tissue regeneration
J Chen, R Zhou, Y Feng, L Cheng - Signal Transduction and Targeted …, 2022 - nature.com
Physical activity has been known as an essential element to promote human health for
centuries. Thus, exercise intervention is encouraged to battle against sedentary lifestyle …
centuries. Thus, exercise intervention is encouraged to battle against sedentary lifestyle …
[HTML][HTML] Mechanical tumor microenvironment and transduction: cytoskeleton mediates cancer cell invasion and metastasis
X Li, J Wang - International journal of biological sciences, 2020 - ncbi.nlm.nih.gov
Metastasis is a complicated, multistep process that is responsible for over 90% of cancer-
related death. Metastatic disease or the movement of cancer cells from one site to another …
related death. Metastatic disease or the movement of cancer cells from one site to another …
Dynamic Stimulations with Bioengineered Extracellular Matrix‐Mimicking Hydrogels for Mechano Cell Reprogramming and Therapy
Cells interact with their surrounding environment through a combination of static and
dynamic mechanical signals that vary over stimulus types, intensity, space, and time …
dynamic mechanical signals that vary over stimulus types, intensity, space, and time …
Dynamic magneto-softening of 3D hydrogel reverses malignant transformation of cancer cells and enhances drug efficacy
High extracellular matrix stiffness is a prominent feature of malignant tumors associated with
poor clinical prognosis. To elucidate mechanistic connections between increased matrix …
poor clinical prognosis. To elucidate mechanistic connections between increased matrix …
Circular RNA circRILPL1 promotes nasopharyngeal carcinoma malignant progression by activating the Hippo-YAP signaling pathway
P Wu, X Hou, M Peng, X Deng, Q Yan, C Fan… - Cell Death & …, 2023 - nature.com
Circular RNAs (circRNAs) play an important regulatory role in the pathogenesis and
progression of nasopharyngeal carcinoma (NPC), which have not been thoroughly …
progression of nasopharyngeal carcinoma (NPC), which have not been thoroughly …
Inhibition of colorectal cancer tumorigenesis by ursolic acid and doxorubicin is mediated by targeting the Akt signaling pathway and activating the Hippo signaling …
D Hu, RY Meng, TV Nguyen… - Molecular …, 2022 - spandidos-publications.com
Colorectal cancer (CRC) is one of the deadliest malignant tumors worldwide and its
prevalence is increasing in South Korea. The efficacy of combined treatment with natural …
prevalence is increasing in South Korea. The efficacy of combined treatment with natural …
[HTML][HTML] Mechanotransduction in tumor dynamics modeling
Mechanotherapy is a groundbreaking approach to impact carcinogenesis. Cells sense and
respond to mechanical stimuli, translating them into biochemical signals in a process known …
respond to mechanical stimuli, translating them into biochemical signals in a process known …
Mechanosensing in embryogenesis
P Agarwal, R Zaidel-Bar - Current Opinion in Cell Biology, 2021 - Elsevier
Mechanical forces generated by living cells at the molecular level propagate to the cellular
and organismal level and have profound consequences for embryogenesis. A direct result of …
and organismal level and have profound consequences for embryogenesis. A direct result of …
Astrocytes control quiescent NSC reactivation via GPCR signaling–mediated F-actin remodeling
The transitioning of neural stem cells (NSCs) between quiescent and proliferative states is
fundamental for brain development and homeostasis. Defects in NSC reactivation are …
fundamental for brain development and homeostasis. Defects in NSC reactivation are …