Structurally dynamic hydrogels for biomedical applications: pursuing a fine balance between macroscopic stability and microscopic dynamics

K Zhang, Q Feng, Z Fang, L Gu, L Bian - Chemical Reviews, 2021 - ACS Publications
Owing to their unique chemical and physical properties, hydrogels are attracting increasing
attention in both basic and translational biomedical studies. Although the classical hydrogels …

Molecular mechanisms of exercise contributing to tissue regeneration

J Chen, R Zhou, Y Feng, L Cheng - Signal Transduction and Targeted …, 2022 - nature.com
Physical activity has been known as an essential element to promote human health for
centuries. Thus, exercise intervention is encouraged to battle against sedentary lifestyle …

[HTML][HTML] Mechanical tumor microenvironment and transduction: cytoskeleton mediates cancer cell invasion and metastasis

X Li, J Wang - International journal of biological sciences, 2020 - ncbi.nlm.nih.gov
Metastasis is a complicated, multistep process that is responsible for over 90% of cancer-
related death. Metastatic disease or the movement of cancer cells from one site to another …

Dynamic Stimulations with Bioengineered Extracellular Matrix‐Mimicking Hydrogels for Mechano Cell Reprogramming and Therapy

Y Shou, XY Teo, KZ Wu, B Bai, ARK Kumar… - Advanced …, 2023 - Wiley Online Library
Cells interact with their surrounding environment through a combination of static and
dynamic mechanical signals that vary over stimulus types, intensity, space, and time …

Dynamic magneto-softening of 3D hydrogel reverses malignant transformation of cancer cells and enhances drug efficacy

Y Shou, XY Teo, X Li, L Zhicheng, L Liu, X Sun… - ACS …, 2023 - ACS Publications
High extracellular matrix stiffness is a prominent feature of malignant tumors associated with
poor clinical prognosis. To elucidate mechanistic connections between increased matrix …

Circular RNA circRILPL1 promotes nasopharyngeal carcinoma malignant progression by activating the Hippo-YAP signaling pathway

P Wu, X Hou, M Peng, X Deng, Q Yan, C Fan… - Cell Death & …, 2023 - nature.com
Circular RNAs (circRNAs) play an important regulatory role in the pathogenesis and
progression of nasopharyngeal carcinoma (NPC), which have not been thoroughly …

Inhibition of colorectal cancer tumorigenesis by ursolic acid and doxorubicin is mediated by targeting the Akt signaling pathway and activating the Hippo signaling …

D Hu, RY Meng, TV Nguyen… - Molecular …, 2022 - spandidos-publications.com
Colorectal cancer (CRC) is one of the deadliest malignant tumors worldwide and its
prevalence is increasing in South Korea. The efficacy of combined treatment with natural …

[HTML][HTML] Mechanotransduction in tumor dynamics modeling

B Blanco, H Gomez, J Melchor, R Palma, J Soler… - Physics of Life …, 2023 - Elsevier
Mechanotherapy is a groundbreaking approach to impact carcinogenesis. Cells sense and
respond to mechanical stimuli, translating them into biochemical signals in a process known …

Mechanosensing in embryogenesis

P Agarwal, R Zaidel-Bar - Current Opinion in Cell Biology, 2021 - Elsevier
Mechanical forces generated by living cells at the molecular level propagate to the cellular
and organismal level and have profound consequences for embryogenesis. A direct result of …

Astrocytes control quiescent NSC reactivation via GPCR signaling–mediated F-actin remodeling

KY Lin, MR Gujar, J Lin, WY Ding, J Huang, Y Gao… - Science …, 2024 - science.org
The transitioning of neural stem cells (NSCs) between quiescent and proliferative states is
fundamental for brain development and homeostasis. Defects in NSC reactivation are …