Carotid body chemoreceptors: physiology, pathology, and implications for health and disease

R Iturriaga, J Alcayaga, MW Chapleau… - Physiological …, 2021 - journals.physiology.org
The carotid body (CB) is the main peripheral chemoreceptor for arterial respiratory gases O2
and CO2 and pH, eliciting reflex ventilatory, cardiovascular, and humoral responses to …

[HTML][HTML] Peripheral chemoreceptors: function and plasticity of the carotid body

P Kumar, NR Prabhakar - Comprehensive Physiology, 2012 - ncbi.nlm.nih.gov
The discovery of the sensory nature of the carotid body dates back to the beginning of the
20th century. Following these seminal discoveries, research into carotid body mechanisms …

The ventilatory response to hypoxia in mammals: mechanisms, measurement, and analysis

LJ Teppema, A Dahan - Physiological reviews, 2010 - journals.physiology.org
The respiratory response to hypoxia in mammals develops from an inhibition of breathing
movements in utero into a sustained increase in ventilation in the adult. This ventilatory …

Neurotransmission in the carotid body: transmitters and modulators between glomus cells and petrosal ganglion nerve terminals

R Iturriaga, J Alcayaga - Brain Research Reviews, 2004 - Elsevier
The carotid body (CB) is the main arterial chemoreceptor. The most accepted model of
arterial chemoreception postulates that carotid body glomus (type I) cells are the primary …

Signal processing at mammalian carotid body chemoreceptors

CA Nurse, NA Piskuric - Seminars in cell & developmental biology, 2013 - Elsevier
Mammalian carotid bodies are richly vascularized chemosensory organs that sense blood
levels of O2, CO2/H+, and glucose and maintain homeostatic regulation of these levels via …

Detection of hypoxia-evoked ATP release from chemoreceptor cells of the rat carotid body

J Buttigieg, CA Nurse - Biochemical and biophysical research …, 2004 - Elsevier
The carotid body (CB) is a chemosensory organ that detects changes in chemical
composition of arterial blood and maintains homeostasis via reflex control of ventilation …

Synapse formation and hypoxic signalling in co‐cultures of rat petrosal neurones and carotid body type 1 cells

H Zhong, M Zhang, CA Nurse - The Journal of Physiology, 1997 - Wiley Online Library
1 To investigate synaptic mechanisms mediating chemosensory signalling in the carotid
body, we developed co‐cultures of chemoreceptor type 1 cell clusters and dissociated …

Caffeine inhibition of rat carotid body chemoreceptors is mediated by A2A and A2B adenosine receptors

SV Conde, A Obeso, I Vicario, R Rigual… - Journal of …, 2006 - Wiley Online Library
Caffeine, an unspecific antagonist of adenosine receptors, is commonly used to treat the
apnea of prematurity. We have defined the effects of caffeine on the carotid body (CB) …

ACh and ATP mediate excitatory transmission in cat carotid identified chemoreceptor units in vitro

R Varas, J Alcayaga, R Iturriaga - Brain research, 2003 - Elsevier
Several molecules have been proposed as excitatory transmitters between glomus (type 1)
cells and nerve terminals of petrosal ganglion (PG) neurons in the carotid body (CB). We …

Neurotransmitters in Carotid Body Function: The Case of Dopamine – Invited Article

R Iturriaga, J Alcayaga, C Gonzalez - Arterial Chemoreceptors: Arterial …, 2009 - Springer
The carotid body (CB) is the main peripheral chemoreceptor. The present model of CB
chemoreception states that glomus (type I) cells are the primary receptors, which are …