From tumour heterogeneity to advances in precision treatment of colorectal cancer

CJA Punt, M Koopman, L Vermeulen - Nature reviews Clinical oncology, 2017 - nature.com
In recent years, the high heterogeneity of colorectal cancer (CRC) has become evident.
Hence, biomarkers need to be developed that enable the stratification of patients with CRC …

The colorectal cancer tumor microenvironment and its impact on liver and lung metastasis

R Chandra, JD Karalis, C Liu, GZ Murimwa, J Voth Park… - Cancers, 2021 - mdpi.com
Simple Summary Colorectal cancer (CRC) is the third most common cancer worldwide.
Metastasis to secondary organs, such as the liver and lungs, is a key driver of CRC-related …

[HTML][HTML] Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients

B Nguyen, C Fong, A Luthra, SA Smith, RG DiNatale… - Cell, 2022 - cell.com
Metastatic progression is the main cause of death in cancer patients, whereas the
underlying genomic mechanisms driving metastasis remain largely unknown. Here, we …

KRAS-IRF2 axis drives immune suppression and immune therapy resistance in colorectal cancer

W Liao, MJ Overman, AT Boutin, X Shang, DI Zhao… - Cancer cell, 2019 - cell.com
The biological functions and mechanisms of oncogenic KRAS G12D (KRAS∗) in resistance
to immune checkpoint blockade (ICB) therapy are not fully understood. We demonstrate that …

[HTML][HTML] The current understanding on the impact of KRAS on colorectal cancer

M Meng, K Zhong, T Jiang, Z Liu, HY Kwan… - Biomedicine & …, 2021 - Elsevier
KRAS (kirsten rat sarcoma viral oncogene) is a member of the RAS family. KRAS mutations
are one of most dominant mutations in colorectal cancer (CRC). The impact of KRAS …

Oncogenic Kras drives invasion and maintains metastases in colorectal cancer

AT Boutin, WT Liao, M Wang, SS Hwang… - Genes & …, 2017 - genesdev.cshlp.org
Human colorectal cancer (CRC) is a major cause of cancer mortality and frequently harbors
activating mutations in the KRAS gene. To understand the role of oncogenic KRAS in CRC …

Genetic insights into the morass of metastatic heterogeneity

KW Hunter, R Amin, S Deasy, NH Ha… - Nature Reviews …, 2018 - nature.com
Tumour heterogeneity poses a substantial problem for the clinical management of cancer.
Somatic evolution of the cancer genome results in genetically distinct subclones in the …

Prevalence of RAS and BRAF mutations in metastatic colorectal cancer patients by tumor sidedness: a systematic review and meta‐analysis

LC Bylsma, C Gillezeau, TA Garawin… - Cancer …, 2020 - Wiley Online Library
Studies have shown that the prevalence of RAS and BRAF mutations may differ by tumor
sidedness among metastatic colorectal cancer (mCRC) patients. Both mutation status and …

Mutant KRAS triggers functional reprogramming of tumor-associated macrophages in colorectal cancer

H Liu, Z Liang, C Zhou, Z Zeng, F Wang, T Hu… - … and Targeted Therapy, 2021 - nature.com
Oncogenic KRAS has been previously identified to act in a cell-intrinsic manner to modulate
multiple biological functions of colorectal cancer (CRC). Here, we demonstrate a cell …

Combined Mutation of Apc, Kras, and Tgfbr2 Effectively Drives Metastasis of Intestinal Cancer

E Sakai, M Nakayama, H Oshima, Y Kouyama, A Niida… - Cancer research, 2018 - AACR
Colorectal cancer is driven by the accumulation of driver mutations, but the contributions of
specific mutations to different steps in malignant progression are not fully understood. In this …