From tumour heterogeneity to advances in precision treatment of colorectal cancer
CJA Punt, M Koopman, L Vermeulen - Nature reviews Clinical oncology, 2017 - nature.com
In recent years, the high heterogeneity of colorectal cancer (CRC) has become evident.
Hence, biomarkers need to be developed that enable the stratification of patients with CRC …
Hence, biomarkers need to be developed that enable the stratification of patients with CRC …
The colorectal cancer tumor microenvironment and its impact on liver and lung metastasis
Simple Summary Colorectal cancer (CRC) is the third most common cancer worldwide.
Metastasis to secondary organs, such as the liver and lungs, is a key driver of CRC-related …
Metastasis to secondary organs, such as the liver and lungs, is a key driver of CRC-related …
[HTML][HTML] Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients
Metastatic progression is the main cause of death in cancer patients, whereas the
underlying genomic mechanisms driving metastasis remain largely unknown. Here, we …
underlying genomic mechanisms driving metastasis remain largely unknown. Here, we …
KRAS-IRF2 axis drives immune suppression and immune therapy resistance in colorectal cancer
The biological functions and mechanisms of oncogenic KRAS G12D (KRAS∗) in resistance
to immune checkpoint blockade (ICB) therapy are not fully understood. We demonstrate that …
to immune checkpoint blockade (ICB) therapy are not fully understood. We demonstrate that …
[HTML][HTML] The current understanding on the impact of KRAS on colorectal cancer
M Meng, K Zhong, T Jiang, Z Liu, HY Kwan… - Biomedicine & …, 2021 - Elsevier
KRAS (kirsten rat sarcoma viral oncogene) is a member of the RAS family. KRAS mutations
are one of most dominant mutations in colorectal cancer (CRC). The impact of KRAS …
are one of most dominant mutations in colorectal cancer (CRC). The impact of KRAS …
Oncogenic Kras drives invasion and maintains metastases in colorectal cancer
AT Boutin, WT Liao, M Wang, SS Hwang… - Genes & …, 2017 - genesdev.cshlp.org
Human colorectal cancer (CRC) is a major cause of cancer mortality and frequently harbors
activating mutations in the KRAS gene. To understand the role of oncogenic KRAS in CRC …
activating mutations in the KRAS gene. To understand the role of oncogenic KRAS in CRC …
Genetic insights into the morass of metastatic heterogeneity
Tumour heterogeneity poses a substantial problem for the clinical management of cancer.
Somatic evolution of the cancer genome results in genetically distinct subclones in the …
Somatic evolution of the cancer genome results in genetically distinct subclones in the …
Prevalence of RAS and BRAF mutations in metastatic colorectal cancer patients by tumor sidedness: a systematic review and meta‐analysis
LC Bylsma, C Gillezeau, TA Garawin… - Cancer …, 2020 - Wiley Online Library
Studies have shown that the prevalence of RAS and BRAF mutations may differ by tumor
sidedness among metastatic colorectal cancer (mCRC) patients. Both mutation status and …
sidedness among metastatic colorectal cancer (mCRC) patients. Both mutation status and …
Mutant KRAS triggers functional reprogramming of tumor-associated macrophages in colorectal cancer
Oncogenic KRAS has been previously identified to act in a cell-intrinsic manner to modulate
multiple biological functions of colorectal cancer (CRC). Here, we demonstrate a cell …
multiple biological functions of colorectal cancer (CRC). Here, we demonstrate a cell …
Combined Mutation of Apc, Kras, and Tgfbr2 Effectively Drives Metastasis of Intestinal Cancer
E Sakai, M Nakayama, H Oshima, Y Kouyama, A Niida… - Cancer research, 2018 - AACR
Colorectal cancer is driven by the accumulation of driver mutations, but the contributions of
specific mutations to different steps in malignant progression are not fully understood. In this …
specific mutations to different steps in malignant progression are not fully understood. In this …