Polypharmacy: evaluating risks and deprescribing

AD Halli-Tierney, C Scarbrough, D Carroll - American family physician, 2019 - aafp.org
Polypharmacy, defined as regular use of at least five medications, is common in older adults
and younger at-risk populations and increases the risk of adverse medical outcomes. There …

The feasibility and effect of deprescribing in older adults on mortality and health: a systematic review and meta‐analysis

AT Page, RM Clifford, K Potter… - British journal of …, 2016 - Wiley Online Library
Aims Deprescribing is a suggested intervention to reverse the potential iatrogenic harms of
inappropriate polypharmacy. The review aimed to determine whether or not deprescribing is …

The Asia-Pacific clinical practice guidelines for the management of frailty

E Dent, C Lien, WS Lim, WC Wong, CH Wong… - Journal of the American …, 2017 - Elsevier
Abstract Objective To develop Clinical Practice Guidelines for the screening, assessment
and management of the geriatric condition of frailty. Methods An adapted Grading of …

Adverse drug reactions in older adults: a narrative review of the literature

MB Zazzara, K Palmer, DL Vetrano, A Carfì… - European geriatric …, 2021 - Springer
Abstract Purpose Adverse drug reactions (ADRs) represent a common and potentially
preventable cause of unplanned hospitalization, increasing morbidity, mortality, and …

Deprescribing: a narrative review of the evidence and practical recommendations for recognizing opportunities and taking action

E Reeve, W Thompson, B Farrell - European journal of internal medicine, 2017 - Elsevier
Deprescribing can be defined as the process of withdrawal or dose reduction of medications
which are considered inappropriate in an individual. The aim of this narrative review is to …

Polypharmacy management in the older adults: a scoping review of available interventions

M Kurczewska-Michalak, P Lewek… - Frontiers in …, 2021 - frontiersin.org
Background: Polypharmacy paves the way for non-adherence, adverse drug reactions,
negative health outcomes, increased use of healthcare services and rising costs. Since it is …

Consumer attitudes towards deprescribing: a systematic review and meta-analysis

KR Weir, NJ Ailabouni, CR Schneider… - The Journals of …, 2022 - academic.oup.com
Background Harmful and/or unnecessary medication use in older adults is common. This
indicates deprescribing (supervised withdrawal of inappropriate medicines) is not …

Assessment of attitudes toward deprescribing in older Medicare beneficiaries in the United States

E Reeve, JL Wolff, M Skehan, EA Bayliss… - JAMA internal …, 2018 - jamanetwork.com
Importance Use of harmful and/or unnecessary medications in older adults is prevalent. This
can lead to avoidable harms such as adverse drug reactions, falls, hospitalization, and …

Deprescribing in older adults with cardiovascular disease

A Krishnaswami, MA Steinman, P Goyal… - Journal of the American …, 2019 - jacc.org
Deprescribing, an integral component of a continuum of good prescribing practices, is the
process of medication withdrawal or dose reduction to correct or prevent medication-related …

Impact of deprescribing interventions in older hospitalised patients on prescribing and clinical outcomes: a systematic review of randomised trials

J Thillainadesan, D Gnjidic, S Green, SN Hilmer - Drugs & aging, 2018 - Springer
Background Polypharmacy and potentially inappropriate medications (PIMs) are prevalent
in older adults in hospital, and are associated with negative outcomes including adverse …