Bone development is characterized by complex regulation mechanisms, including signal
transduction and transcription factor-related pathways, glycobiological processes, cellular …

The unique structure and composition of articular cartilage is critical for its physiological
function. However, this architecture may get disrupted by degeneration or trauma. Due to the …

Musculoskeletal disorders represent one of the main causes of disability worldwide, and
their prevalence is predicted to increase in the coming decades. Stem cell therapy may be a …

Lower back pain is a common disability associated with aging that continues to carry a huge
economic and health burden globally. Importantly, lower back pain is strongly associated …

Heat stress (HS) exerts detrimental effects on animal production, with lactating sows being
particularly vulnerable. Understanding the mechanisms involved in HS response could aid …

Morning-time heart attacks are associated with an ablation in the sleep-time dip in blood
pressure, the mechanism of which is unknown. The epigenetic changes are the hallmark of …

Peripheral circadian clocks control cell proliferation and survival, but little is known about
their role and regulation in megakaryocytic cells. N-methyl-D-aspartate receptor (NMDAR) …

Objective To explore the relationship between the proinflammatory factor high‐mobility
group box 1 (HMGB1) and glutamatergic alpha-amino-3-hydroxy-5-methyl-4 …

Osteoarthritis (OA) is a degenerative disease caused by multiple factors. This study used in
vitro and animal models to investigate the connection between the biological clock and cell …

Melatonin, a neurohormone, improves hepatic function in diet and/or chronodisruption in
Metabolic dysfunction Associated with Steatotic Liver Disease (MASLD). Nocturnin (Noct), a …