The role of adipokines in health and disease

VJ Clemente-Suárez, L Redondo-Flórez… - Biomedicines, 2023 - mdpi.com
Adipokines are cell-signaling proteins secreted by adipose tissue that has been related to a
low-grade state of inflammation and different pathologies. The present review aims to …

Browning of the white adipose tissue regulation: New insights into nutritional and metabolic relevance in health and diseases

SA Machado, G Pasquarelli-do-Nascimento… - Nutrition & …, 2022 - Springer
Adipose tissues are dynamic tissues that play crucial physiological roles in maintaining
health and homeostasis. Although white adipose tissue and brown adipose tissue are …

Adipose tissue macrophage-derived exosomal miRNAs can modulate in vivo and in vitro insulin sensitivity

W Ying, M Riopel, G Bandyopadhyay, Y Dong… - Cell, 2017 - cell.com
MiRNAs are regulatory molecules that can be packaged into exosomes and secreted from
cells. Here, we show that adipose tissue macrophages (ATMs) in obese mice secrete …

Apoptotic brown adipocytes enhance energy expenditure via extracellular inosine

B Niemann, S Haufs-Brusberg, L Puetz, M Feickert… - Nature, 2022 - nature.com
Brown adipose tissue (BAT) dissipates energy, and promotes cardiometabolic health. Loss
of BAT during obesity and ageing is a principal hurdle for BAT-centred obesity therapies, but …

Pathophysiology of systemic sclerosis: current understanding and new insights

M Cutolo, S Soldano, V Smith - Expert review of clinical …, 2019 - Taylor & Francis
ABSTRACT Introduction: Systemic sclerosis (SSc) is a complex autoimmune connective
tissue disease characterized by chronic and progressive tissue and organ fibrosis with …

Brown and beige fat: physiological roles beyond heat generation

S Kajimura, BM Spiegelman, P Seale - Cell metabolism, 2015 - cell.com
Since brown adipose tissue (BAT) dissipates energy through UCP1, BAT has garnered
attention as a therapeutic intervention for obesity and metabolic diseases including type 2 …

Cell–cell communication: new insights and clinical implications

J Su, Y Song, Z Zhu, X Huang, J Fan, J Qiao… - Signal Transduction and …, 2024 - nature.com
Multicellular organisms are composed of diverse cell types that must coordinate their
behaviors through communication. Cell–cell communication (CCC) is essential for growth …

Adipose tissue browning and metabolic health

A Bartelt, J Heeren - Nature Reviews Endocrinology, 2014 - nature.com
Accumulation of excess white adipose tissue (WAT) has deleterious consequences for
metabolic health. The activation of brown adipose tissue (BAT), the primary organ for heat …

Exosome-derived microRNAs of human milk and their effects on infant health and development

BC Melnik, W Stremmel, R Weiskirchen, SM John… - Biomolecules, 2021 - mdpi.com
Multiple biologically active components of human milk support infant growth, health and
development. Milk provides a wide spectrum of mammary epithelial cell-derived …

Micro RNA s in metabolism

S Vienberg, J Geiger, S Madsen… - Acta …, 2017 - Wiley Online Library
Micro RNA s (mi RNA s) have within the past decade emerged as key regulators of
metabolic homoeostasis. Major tissues in intermediary metabolism important during …