Structures and biological functions of zinc finger proteins and their roles in hepatocellular carcinoma

X Li, M Han, H Zhang, F Liu, Y Pan, J Zhu, Z Liao… - Biomarker …, 2022 - Springer
Zinc finger proteins are transcription factors with the finger domain, which plays a significant
role in gene regulation. As the largest family of transcription factors in the human genome …

KRAB-ZFP transcriptional regulators acting as oncogenes and tumor suppressors: an overview

J Sobocińska, S Molenda, M Machnik… - International journal of …, 2021 - mdpi.com
Krüppel-associated box zinc finger proteins (KRAB-ZFPs) constitute the largest family of
transcriptional factors exerting co-repressor functions in mammalian cells. In general, KRAB …

Crucial role of the transcription factors family activator protein 2 in cancer: current clue and views

C Jin, Y Luo, Z Liang, X Li, D Kołat, L Zhao… - Journal of Translational …, 2023 - Springer
The transcription factor family activator protein 2 (TFAP2) is vital for regulating both
embryonic and oncogenic development. The TFAP2 family consists of five DNA-binding …

Plastin 3 in health and disease: a matter of balance

L Wolff, EA Strathmann, I Müller, D Mählich… - Cellular and Molecular …, 2021 - Springer
For a long time, PLS3 (plastin 3, also known as T-plastin or fimbrin) has been considered a
rather inconspicuous protein, involved in F-actin-binding and-bundling. However, in recent …

[HTML][HTML] The signaling pathways regulated by KRAB zinc-finger proteins in cancer

M Sun, J Ju, Y Ding, C Zhao, C Tian - … et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
Kruppel-associated box (KRAB) zinc-finger proteins (KRAB-ZFPs) are the largest
transcriptional/transcription-regulatory factor family in mammalian cells. The amino-terminal …

Curcumin suppresses LGR5 (+) colorectal cancer stem cells by inducing autophagy and via repressing TFAP2A-mediated ECM pathway

X Mao, X Zhang, X Zheng, Y Chen, Z Xuan… - Journal of natural …, 2021 - Springer
Colorectal cancer stem cells (CSCs) have the potential for self-renewal, proliferation, and
differentiation. And LGR5 is a stem cell marker gene of colorectal cancer. Curcumin can …

The translational values of TRIM family in pan-cancers: From functions and mechanisms to clinics

G Zhao, C Liu, X Wen, G Luan, L Xie, X Guo - Pharmacology & …, 2021 - Elsevier
Cancer is the second leading cause of human death across the world. Tripartite motif (TRIM)
family, with E3 ubiquitin ligase activities in majority of its members, is reported to be involved …

The Dual-Response–Single-Amplification Fluorescent Nanomachine for Tumor Imaging and Gastric Cancer Diagnosis

P Zhang, Y Tong, X Huang, Y Chen, Y Li, D Luan, J Li… - ACS …, 2023 - ACS Publications
Gastric cancer (GC) is one of the most common tumors worldwide and is the leading cause
of tumor-related mortality. Traditional biomarkers and screening methods cannot meet the …

Zinc finger proteins in the war on gastric cancer: Molecular mechanism and clinical potential

S Liu, X Liu, X Lin, H Chen - Cells, 2023 - mdpi.com
According to the 2020 global cancer data released by the World Cancer Research Fund
(WCRF) International, gastric cancer (GC) is the fifth most common cancer worldwide, with …

lncRNA LIFR-AS1 suppresses invasion and metastasis of non-small cell lung cancer via the miR-942-5p/ZNF471 axis

Q Wang, J Wu, H Huang, Y Jiang, Y Huang… - Cancer cell …, 2020 - Springer
Abstract Background MicroRNA 942-5p (miR-942-5p) has been reported to promote
migration and invasion in non-small cell lung cancer (NSCLC), but the underlying …