Drivers and consequences of bacteriophage host range
D Holtappels, P Alfenas-Zerbini… - FEMS Microbiology …, 2023 - academic.oup.com
Bacteriophages are obligate parasites of bacteria characterized by the breadth of hosts that
they can infect. This “host range” depends on the genotypes and morphologies of the phage …
they can infect. This “host range” depends on the genotypes and morphologies of the phage …
[HTML][HTML] The dynamic interplay of bacteriophage, bacteria and the mammalian host during phage therapy
J Marchi, S Zborowsky, L Debarbieux, JS Weitz - Iscience, 2023 - cell.com
For decades, biomedically centered studies of bacteria have focused on mechanistic drivers
of disease in their mammalian hosts. Likewise, molecular studies of bacteriophage have …
of disease in their mammalian hosts. Likewise, molecular studies of bacteriophage have …
Coevolutionary phage training leads to greater bacterial suppression and delays the evolution of phage resistance
The evolution of antibiotic-resistant bacteria threatens to become the leading cause of
worldwide mortality. This crisis has renewed interest in the practice of phage therapy. Yet …
worldwide mortality. This crisis has renewed interest in the practice of phage therapy. Yet …
Rapid bacteria-phage coevolution drives the emergence of multiscale networks
Interactions between species catalyze the evolution of multiscale ecological networks,
including both nested and modular elements that regulate the function of diverse …
including both nested and modular elements that regulate the function of diverse …
Bacteria-phage coevolution with a seed bank
DA Schwartz, WR Shoemaker, A Măgălie… - The ISME …, 2023 - academic.oup.com
Dormancy is an adaptation to living in fluctuating environments. It allows individuals to enter
a reversible state of reduced metabolic activity when challenged by unfavorable conditions …
a reversible state of reduced metabolic activity when challenged by unfavorable conditions …
Comparison of bacterial suppression by phage cocktails, dual‐receptor generalists, and coevolutionarily trained phages
JM Borin, JJ Lee, KR Gerbino… - Evolutionary …, 2023 - Wiley Online Library
The evolution and spread of antibiotic‐resistant bacteria have renewed interest in phage
therapy, the use of bacterial viruses (phages) to combat bacterial infections. The delivery of …
therapy, the use of bacterial viruses (phages) to combat bacterial infections. The delivery of …
Sustained coevolution of phage Lambda and Escherichia coli involves inner- as well as outer-membrane defences and counter-defences
AR Burmeister, RM Sullivan, J Gallie… - …, 2021 - microbiologyresearch.org
Bacteria often evolve resistance to phage through the loss or modification of cell surface
receptors. In Escherichia coli and phage λ, such resistance can catalyze a coevolutionary …
receptors. In Escherichia coli and phage λ, such resistance can catalyze a coevolutionary …
Strong selection and high mutation supply characterize experimental Chlorovirus evolution
Characterizing how viruses evolve expands our understanding of the underlying
fundamental processes, such as mutation, selection and drift. One group of viruses whose …
fundamental processes, such as mutation, selection and drift. One group of viruses whose …
The dimensionality of infection networks among viruses infecting microbial eukaryotes and bacteria
KF Edwards, C Hayward - Ecology Letters, 2024 - Wiley Online Library
Diverse viruses and their hosts are interconnected through complex networks of infection,
which are thought to influence ecological and evolutionary processes, but the principles …
which are thought to influence ecological and evolutionary processes, but the principles …
More evolvable bacteriophages better suppress their host
EK Horwitz, HM Strobel, J Haiso… - Evolutionary …, 2024 - Wiley Online Library
The number of multidrug‐resistant strains of bacteria is increasing rapidly, while the number
of new antibiotic discoveries has stagnated. This trend has caused a surge in interest in …
of new antibiotic discoveries has stagnated. This trend has caused a surge in interest in …