Identification of two archaeal GDGT lipid–modifying proteins reveals diverse microbes capable of GMGT biosynthesis and modification
AA Garcia, GL Chadwick, XL Liu… - Proceedings of the …, 2024 - National Acad Sciences
Archaea produce unique membrane-spanning lipids (MSLs), termed glycerol dialkyl glycerol
tetraethers (GDGTs), which aid in adaptive responses to various environmental challenges …
tetraethers (GDGTs), which aid in adaptive responses to various environmental challenges …
Intein splicing efficiency and RadA levels can control the mode of archaeal DNA replication
Inteins (intervening proteins), mobile genetic elements removed through protein splicing,
often interrupt proteins required for DNA replication, recombination, and repair. An …
often interrupt proteins required for DNA replication, recombination, and repair. An …
Histones direct site-specific CRISPR spacer acquisition in model archaeon
EA Watts, SC Garrett, RJ Catchpole, LM Clark… - Nature …, 2023 - nature.com
CRISPR–Cas systems provide heritable immunity against viruses and other mobile genetic
elements by incorporating fragments of invader DNA into the host CRISPR array as spacers …
elements by incorporating fragments of invader DNA into the host CRISPR array as spacers …
Tetraether archaeal lipids promote long‐term survival in extreme conditions
GLS Liman, AA Garcia, KA Fluke… - Molecular …, 2024 - Wiley Online Library
The sole unifying feature of the incredibly diverse Archaea is their isoprenoid‐based ether‐
linked lipid membranes. Unique lipid membrane composition, including an abundance of …
linked lipid membranes. Unique lipid membrane composition, including an abundance of …
Thermococcus kodakarensis TK0353 is a novel AP lyase with a new fold
PJ Caffrey, BE Eckenroth, BW Burkhart… - Journal of Biological …, 2024 - ASBMB
Hyperthermophilic organisms thrive in extreme environments prone to high levels of DNA
damage. Growth at high temperature stimulates DNA base hydrolysis resulting in …
damage. Growth at high temperature stimulates DNA base hydrolysis resulting in …