Homocysteine–from disease biomarker to disease prevention

AD Smith, H Refsum - Journal of internal medicine, 2021 - Wiley Online Library
We have reviewed the literature and have identified more than 100 diseases or conditions
that are associated with raised concentrations of plasma total homocysteine. The …

[HTML][HTML] Implication of hyperhomocysteinemia in blood retinal barrier (BRB) dysfunction

A Tawfik, YA Samra, NM Elsherbiny, M Al-Shabrawey - Biomolecules, 2020 - mdpi.com
Elevated plasma homocysteine (Hcy) level, known as hyperhomocysteinemia (HHcy) has
been linked to different systemic and neurological diseases, well-known as a risk factor for …

Paraoxonase 1 and homocysteine metabolism

J Perła-Kaján, H Jakubowski - Amino acids, 2012 - Springer
Abstract Paraoxonase 1 (PON1), a component of high-density lipoprotein (HDL), is a
calcium-dependent multifunctional enzyme that connects metabolisms of lipoproteins and …

[HTML][HTML] Accurate image analysis of the retina using hessian matrix and binarisation of thresholded entropy with application of texture mapping

X Yin, BWH Ng, J He, Y Zhang, D Abbott - PloS one, 2014 - journals.plos.org
In this paper, we demonstrate a comprehensive method for segmenting the retinal
vasculature in camera images of the fundus. This is of interest in the area of diagnostics for …

[HTML][HTML] Rebuilding microbiome for mitigating traumatic brain injury: importance of restructuring the gut-microbiome-brain axis

AK George, J Behera, RP Homme, N Tyagi… - Molecular …, 2021 - Springer
Traumatic brain injury (TBI) is a damage to the brain from an external force that results in
temporary or permanent impairment in brain functions. Unfortunately, not many treatment …

Homocysteine in ocular diseases

TA Ajith - Clinica Chimica Acta, 2015 - Elsevier
Homocysteine (Hcy) is a derived sulfur-containing and non-proteinogenic amino acid. The
metabolism of Hcy occurs either through the remethylation to methionine or transsulfuration …

Homocysteine and progression of generalized small-vessel disease: the SMART-MR Study

RP Kloppenborg, MI Geerlings, FL Visseren… - Neurology, 2014 - AAN Enterprises
Objectives: Assuming the involvement of homocysteine in a generalized small-vessel
disease, we investigated the association of homocysteine levels with progression of white …

[HTML][HTML] Hyperhomocysteinemia alters retinal endothelial cells barrier function and angiogenic potential via activation of oxidative stress

R Mohamed, I Sharma, AS Ibrahim, H Saleh… - Scientific reports, 2017 - nature.com
Hyperhomocysteinemia (HHcy) is associated with several human visual disorders, such as
diabetic retinopathy (DR) and age-related macular degeneration (AMD). Breakdown of the …

[HTML][HTML] Intravitreal homocysteine-thiolactone injection leads to the degeneration of multiple retinal cells, including photoreceptors

HH Chang, DPC Lin, YS Chen, HJ Liu, W Lin… - Molecular …, 2011 - ncbi.nlm.nih.gov
Purpose Hyperhomocysteinemia is known to cause degeneration of retinal ganglion cells,
but its influence on photoreceptors remains largely unknown. In particular, the role of …

The influence of age and central foveal thickness on foveal zone size in healthy people

D Gong, X Zou, X Zhang, W Yu, Y Qu… - … Surgery, Lasers and …, 2016 - journals.healio.com
BACKGROUND AND OBJECTIVE: To investigate the influence of age and central foveal
thickness (CFT) on the foveal avascular zone (FAZ) size in healthy people using optical …