Major depression is a prevalent illness that increases the risk of several neurological
conditions. These include stroke, cardiovascular disease, and dementia including …

Serotonin is a key neurotransmitter that is implicated in a wide variety of behavioral and
cognitive phenotypes. Originating in the raphe nuclei, 5-HT neurons project widely to …

Background. Physical exercise (PE) has been associated with increase neuroplasticity,
neurotrophic factors, and improvements in brain function. Objective. To evaluate the effects …

Background A subanesthetic dose of ketamine provides rapid and effective antidepressant
effects, but the molecular mechanism remains elusive. It has been reported that …

Major depression and anxiety are highly prevalent and involve chronic dysregulation of
serotonin, but they remain poorly understood. Here, we review novel transcriptional (genetic …

Chronic treatment with fluoxetine (FLX) is required for its antidepressant effects, but the role
of serotonin (5-HT) axonal plasticity in FLX action is unknown. To address this, we examined …

Pharmacological interventions that selectively activate serotonin 5-hydroxytryptramine-1A (5-
HT 1A) heteroreceptors may prevent or attenuate the consequences of brain ischemic …

Currently, there is an unmet need for treatments promoting post-stroke functional recovery.
The aim of this study was to evaluate and compare the dose-dependent effect of delayed …

The disappointing results in bench-to-bedside translation of neuroprotective strategies
caused a certain shift in stroke research towards enhancing the endogenous recovery …

We aimed to investigate the anti-inflammatory role of fluoxetine, a selective serotonin
reuptake inhibitor, in microglia (MG) and the mechanisms under oxygen glucose …