Irreversible electroporation combined with checkpoint blockade and TLR7 stimulation induces antitumor immunity in a murine pancreatic cancer model
JSS Narayanan, P Ray, T Hayashi, TC Whisenant… - Cancer immunology …, 2019 - AACR
Irreversible electroporation (IRE) is a nonthermal ablation technique that is used clinically in
selected patients with locally advanced pancreatic cancer, but most patients develop …
selected patients with locally advanced pancreatic cancer, but most patients develop …
Expanding the spectrum of pancreatic cancers responsive to vesicular stomatitis virus-based oncolytic virotherapy: challenges and solutions
MC Holbrook, DW Goad, VZ Grdzelishvili - Cancers, 2021 - mdpi.com
Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is a devastating malignancy
with a poor prognosis and a dismal survival rate. Oncolytic virus (OV) is an anticancer …
with a poor prognosis and a dismal survival rate. Oncolytic virus (OV) is an anticancer …
[HTML][HTML] Pressure-Enabled Drug Delivery (PEDD) of a class C TLR9 agonist in combination with checkpoint inhibitor therapy in a murine pancreatic cancer model
BA Capacio, JSS Narayanan, DA Vicente, Y Liu… - Surgery, 2023 - Elsevier
Background Systemic immunotherapy has had limited clinical benefit in pancreatic ductal
adenocarcinoma. This is thought to be due to its desmoplastic immunosuppressive tumor …
adenocarcinoma. This is thought to be due to its desmoplastic immunosuppressive tumor …
[HTML][HTML] Treatment of pancreatic cancer with irreversible electroporation and intratumoral CD40 antibody stimulates systemic immune responses that inhibit liver …
JSS Narayanan, T Hayashi, S Erdem… - … for ImmunoTherapy of …, 2023 - ncbi.nlm.nih.gov
Background Pancreatic cancer (PC) has a poor prognosis, and most patients present with
either locally advanced or distant metastatic disease. Irreversible electroporation (IRE) is a …
either locally advanced or distant metastatic disease. Irreversible electroporation (IRE) is a …
Pressure-enabled delivery of gemcitabine in an orthotopic pancreatic cancer mouse model
JSS Narayanan, DA Vicente, P Ray, LF Chai, S Erdem… - Surgery, 2020 - Elsevier
Background We describe the use of pancreatic retrograde venous infusion in an orthotopic
murine model of pancreatic ductal adenocarcinoma and hypothesize that pancreatic …
murine model of pancreatic ductal adenocarcinoma and hypothesize that pancreatic …
Oxaliplatin-induced peripheral neuropathy can be minimized by pressurized regional intravascular delivery in an orthotopic murine pancreatic cancer model
JSN Shankara Narayanan, K Frizzi, S Erdem, P Ray… - Discover Oncology, 2022 - Springer
Purpose There is a great need to reduce the toxicity of chemotherapy used in the
management of pancreatic ductal adenocarcinoma (PDAC). Here we explore if regional …
management of pancreatic ductal adenocarcinoma (PDAC). Here we explore if regional …
Inhibition of SUMOylation Induces Adaptive Antitumor Immunity against Pancreatic Cancer through Multiple Effects on the Tumor Microenvironment
S Erdem, HJ Lee… - Molecular Cancer …, 2024 - aacrjournals.org
Improvement of outcome in patients with pancreatic ductal adenocarcinoma (PDAC)
requires exploration of novel therapeutic targets. Thus far, most studies of PDAC therapies …
requires exploration of novel therapeutic targets. Thus far, most studies of PDAC therapies …
[HTML][HTML] Irreversible electroporation for the management of pancreatic cancer: Current data and future directions
S Spiliopoulos, L Reppas, D Filippiadis… - World Journal of …, 2023 - ncbi.nlm.nih.gov
Pancreatic cancer is currently the seventh leading cause of cancer death (4.5% of all cancer
deaths) while 80%-90% of the patients suffer from unresectable disease at the time of …
deaths) while 80%-90% of the patients suffer from unresectable disease at the time of …
[PDF][PDF] Evaluation of the energetic cost of bacterial elimination of E. Coli using the electroporation technique in cuvette vessels
S Plasencia Gutiérrez - 2021 - core.ac.uk
In the last two years, the percentage of cases in Peru linked to diarrheal diseases in children
has been considerably reduced, demonstrating that even in difficult times health must …
has been considerably reduced, demonstrating that even in difficult times health must …
[引用][C] Immunotherapy of solid tumors: multimodal imaging strategies for chimeric antigen receptor T cell tracking in the tumor microenvironment
J Henze - 2021 - Dissertation, Göttingen, Georg …