Importance Increasing evidence indicates that acute kidney injury (AKI) occurs frequently in
children and young adults and is associated with poor short-term and long-term outcomes …

Major depressive disorder, or depression, is one of the most common mental illnesses
worldwide. This prevalent mental disorder can trigger numerous concurrent problems …

Pharmacogenomics (PGx), examining the effect of genetic variation on interpatient variation
in drug disposition and response, has been widely studied for several decades. However, as …

Combination antidepressant pharmacotherapies are frequently used to treat major
depressive disorder (MDD). However, there is no evidence that machine learning …

In a pharmaceutical context, metabolomics is an underexplored area of research.
Nevertheless, its utility in clinical pathology, biomarker discovery, metabolic subtyping, and …

Stress, encompassing psychological, physical, and physiological challenges, is an important
factor affecting an individual's well-being and potentially leading to psychiatric …

The pathological diagnosis of benign and malignant follicular thyroid tumors remains a
major challenge using the current histopathological technique. To improve diagnosis …

Abstract Introduction: Rate-limiting enzymes (RLEs) are innate slow points in metabolic
pathways, and many function in bio-processes related to nutrient sensing. Many RLEs carry …

Age at depressive onset (AAO) corresponds to unique symptomatology and clinical
outcomes. Integration of genome-wide association study (GWAS) results with additional …

Antidepressant medications are frequently used as the first line of treatment for depression.
However, their effectiveness is highly variable and influenced by genetic factors. Recently …