Cholinergic system changes in Parkinson's disease: emerging therapeutic approaches
In patients with Parkinson's disease, heterogeneous cholinergic system changes can occur
in different brain regions. These changes correlate with a range of clinical features, both …
in different brain regions. These changes correlate with a range of clinical features, both …
Pathophysiology of motor dysfunction in Parkinson's disease as the rationale for drug treatment and rehabilitation
F Magrinelli, A Picelli, P Tocco, A Federico… - Parkinson's …, 2016 - Wiley Online Library
Cardinal motor features of Parkinson's disease (PD) include bradykinesia, rest tremor, and
rigidity, which appear in the early stages of the disease and largely depend on …
rigidity, which appear in the early stages of the disease and largely depend on …
Soft robotic apparel to avert freezing of gait in Parkinson's disease
Freezing of gait (FoG) is a profoundly disruptive gait disturbance in Parkinson's disease,
causing unintended stops while walking. Therapies for FoG reveal modest and transient …
causing unintended stops while walking. Therapies for FoG reveal modest and transient …
Freezing of gait in Parkinson's disease: pathophysiology, risk factors and treatments
C Gao, J Liu, Y Tan, S Chen - Translational neurodegeneration, 2020 - Springer
Background Freezing of gait (FOG) is a common, disabling symptom of Parkinson's disease
(PD), but the mechanisms and treatments of FOG remain great challenges for clinicians and …
(PD), but the mechanisms and treatments of FOG remain great challenges for clinicians and …
Natural history of motor symptoms in Parkinson's disease and the long-duration response to levodopa
The natural pattern of progression of Parkinson's disease is largely unknown because
patients are conventionally followed on treatment. As Parkinson's disease progresses, the …
patients are conventionally followed on treatment. As Parkinson's disease progresses, the …
A systematic review on exercise and training-based interventions for freezing of gait in Parkinson's disease
Freezing of gait (FOG) in Parkinson's disease (PD) causes severe patient burden despite
pharmacological management. Exercise and training are therefore advocated as important …
pharmacological management. Exercise and training are therefore advocated as important …
Axial disability and deep brain stimulation in patients with Parkinson disease
Axial motor signs—including gait impairment, postural instability and postural abnormalities—
are common and debilitating symptoms in patients with advanced Parkinson disease …
are common and debilitating symptoms in patients with advanced Parkinson disease …
Model-based and model-free machine learning techniques for diagnostic prediction and classification of clinical outcomes in Parkinson's disease
In this study, we apply a multidisciplinary approach to investigate falls in PD patients using
clinical, demographic and neuroimaging data from two independent initiatives (University of …
clinical, demographic and neuroimaging data from two independent initiatives (University of …
Freezing of gait in Parkinson's disease reflects a sudden derangement of locomotor network dynamics
Freezing of gait is a disabling symptom of Parkinson's disease that causes a paroxysmal
inability to generate effective stepping. The underlying pathophysiology has recently …
inability to generate effective stepping. The underlying pathophysiology has recently …
Health-related quality of life in patients with Parkinson's disease—a systematic review based on the ICF model
JMT van Uem, J Marinus, C Canning… - Neuroscience & …, 2016 - Elsevier
We analyzed features associated with a reduction in Health-Related Quality of Life (HRQoL)
in people with idiopathic Parkinson's disease (PD). As a new approach, features were …
in people with idiopathic Parkinson's disease (PD). As a new approach, features were …