Single-cell multi-omics technologies have revolutionized cancer research by allowing us to
examine individual cells at a molecular level. Unlike traditional bulk omics approaches …

Chromosome conformation capture technologies that provide frequency information for
contacts between genomic regions have been crucial for increasing our understanding of …

Abstract We previously reported Paired-Tag, a combinatorial indexing-based method that
can simultaneously map histone modifications and gene expression at single-cell resolution …

The cerebellum contains most of the neurons in the human brain and exhibits distinctive
modes of development and aging. In this work, by developing our single-cell three …

DNA adducts and strand breaks are induced by various exogenous and endogenous
agents. Accumulation of DNA damage is implicated in many disease processes, including …

The structure and dynamics of the eukaryotic genome are intimately linked to gene
regulation and transcriptional activity. Many chromosome conformation capture experiments …

Myofibres serve as the functional unit for locomotion, with the sarcomere as fundamental
subunit. Running the entire length of this structure are hundreds of myonuclei, located at the …

Abstract Single‐cell Hi‐C (scHi‐C) has made it possible to analyze chromatin organization
at the single‐cell level. However, scHi‐C experiments generate inherently sparse data …

The cerebellum contains most of the neurons in the human brain, and exhibits unique
modes of development, malformation, and aging. For example, granule cells—the most …

We present ChromoSkein, a web-based tool for visualizing three-dimensional chromatin
models. The spatial organization of chromatin is essential to its function. Experimental …