MicroRNAs (miRNAs) are small noncoding RNAs with gene regulatory functions and are
commonly dysregulated in disease states. As miRNAs are relatively stable, easily measured …

The haemostatic system is pivotal to maintaining vascular integrity. Multiple components
involved in blood coagulation have central functions in inflammation and immunity. A …

MicroRNAs (miRNA) play an important role in gene expression at the posttranscriptional
level by targeting the untranslated regions of messenger RNA (mRNAs). These small RNAs …

Chemical and UV light-based pathogen reduction technologies are currently in use for
human platelet concentrates (PCs) to enhance safety from transfusion-transmitted infections …

Introduction Elevated markers of endothelial dysfunction and inflammation indicate worse
endothelial function in the aging haemophilia population. MicroRNAs (miRNAs) regulate …

Introduction Conventional genetic investigation fails to identify the F8 causal variant in 2.5%‐
10% of haemophilia A (HA) patients with non‐severe phenotypes. In these cases, F8 deep …

Background The causative variant remains unidentified in 2%–5% of haemophilia A (HA)
patients despite an exhaustive sequencing of the full F8 coding sequence, splice consensus …

Acquired haemophilia (AH) is a rare disorder characterized by bleeding in patients with no
personal or family history of coagulation/clotting‐related diseases. This disease occurs …

Introduction: Coagulation Factor VIII (FVIII) plays a pivotal role in the coagulation cascade,
and deficiencies in its levels, as seen in Hemophilia A, can lead to significant health …

Hemophilia A (HA) is a F8 gene mutational disorder resulting in deficiency or dysfunctional
FVIII protein. However, surprisingly, in few cases, HA is manifested even without mutations …