Loss of tumor suppressor gene function in human cancer: an overview
LH Wang, CF Wu, N Rajasekaran… - Cellular Physiology and …, 2019 - karger.com
Cancer is a disease caused by the accumulation of genetic and epigenetic changes in two
types of genes: tumor suppressor genes (TSGs) and proto-oncogenes. Extensive research …
types of genes: tumor suppressor genes (TSGs) and proto-oncogenes. Extensive research …
Endocrine resistance in hormone receptor positive breast cancer–from mechanism to therapy
A Rani, J Stebbing, G Giamas, J Murphy - Frontiers in endocrinology, 2019 - frontiersin.org
The importance and role of the estrogen receptor (ER) pathway has been well-documented
in both breast cancer (BC) development and progression. The treatment of choice in women …
in both breast cancer (BC) development and progression. The treatment of choice in women …
The NF1 somatic mutational landscape in sporadic human cancers
C Philpott, H Tovell, IM Frayling, DN Cooper… - Human genomics, 2017 - Springer
Abstract Background Neurofibromatosis type 1 (NF1: Online Mendelian Inheritance in Man
(OMIM)# 162200) is an autosomal dominantly inherited tumour predisposition syndrome …
(OMIM)# 162200) is an autosomal dominantly inherited tumour predisposition syndrome …
Targeted therapies for triple-negative breast cancer: combating a stubborn disease
Triple-negative breast cancers (TNBCs) constitute a heterogeneous subtype of breast
cancers that have a poor clinical outcome. Although no approved targeted therapy is …
cancers that have a poor clinical outcome. Although no approved targeted therapy is …
[HTML][HTML] Deregulation of the EGFR/PI3K/PTEN/Akt/mTORC1 pathway in breast cancer: possibilities for therapeutic intervention
NM Davis, M Sokolosky, K Stadelman, SL Abrams… - Oncotarget, 2014 - ncbi.nlm.nih.gov
Abstract The EGFR/PI3K/PTEN/Akt/mTORC1/GSK-3 pathway plays prominent roles in
malignant transformation, prevention of apoptosis, drug resistance and metastasis. The …
malignant transformation, prevention of apoptosis, drug resistance and metastasis. The …
Ras and Rap1: A tale of two GTPases
S Shah, EJ Brock, K Ji, RR Mattingly - Seminars in cancer biology, 2019 - Elsevier
Ras oncoproteins play pivotal roles in both the development and maintenance of many
tumor types. Unfortunately, these proteins are difficult to directly target using traditional …
tumor types. Unfortunately, these proteins are difficult to directly target using traditional …
The tandem duplicator phenotype is a prevalent genome-wide cancer configuration driven by distinct gene mutations
The tandem duplicator phenotype (TDP) is a genome-wide instability configuration primarily
observed in breast, ovarian, and endometrial carcinomas. Here, we stratify TDP tumors by …
observed in breast, ovarian, and endometrial carcinomas. Here, we stratify TDP tumors by …
[HTML][HTML] The NF1 gene revisited–from bench to bedside
Abstract Neurofibromatosis type 1 (NF1) is a relatively common tumour predisposition
syndrome related to germline aberrations of NF1, a tumour suppressor gene. The gene …
syndrome related to germline aberrations of NF1, a tumour suppressor gene. The gene …
[HTML][HTML] Rationale for targeting the Ras/MAPK pathway in triple-negative breast cancer
JM Giltnane, JM Balko - Discovery medicine, 2014 - discoverymedicine.com
" Triple negative" breast cancer (TNBC) is the most aggressive and least common clinical
subtype of breast cancer. As its nomenclature implies, TNBC lacks specific biomarker …
subtype of breast cancer. As its nomenclature implies, TNBC lacks specific biomarker …
An update on neurofibromatosis type 1-associated gliomas
Neurofibromatosis type 1 (NF1) is an autosomal dominant tumor predisposition syndrome
that affects children and adults. Individuals with NF1 are at high risk for central nervous …
that affects children and adults. Individuals with NF1 are at high risk for central nervous …