Monocarboxylates such as lactate, pyruvate, and the ketone bodies play major roles in
metabolism and must be transported across both the plasma membrane and mitochondrial …

Monocarboxylates such as lactate and pyruvate play a central role in cellular metabolism
and metabolic communication between tissues. Essential to these roles is their rapid …

Tumors contain oxygenated and hypoxic regions, so the tumor cell population is
heterogeneous. Hypoxic tumor cells primarily use glucose for glycolytic energy production …

Altered metabolism in cancer cells is pivotal for tumor growth, most notably by providing
energy, reducing equivalents and building blocks while several metabolites exert a …

The maximal lactate steady state (MLSS) is defined as the highest blood lactate
concentration (MLSSc) and work load (MLSSw) that can be maintained over time without a …

We hypothesized that in addition to serving as a fuel source and gluconeogenic precursor,
lactate anion (La−) is a signaling molecule. Therefore, we screened genome‐wide …

Skeletal muscle is the major producer of lactic acid in the body, but its oxidative fibres also
use lactic acid as a respiratory fuel. The stereoselective transport of L‐lactic acid across the …

To evaluate the effects of endurance training on the expression of monocarboxylate
transporters (MCT) in human vastus lateralis muscle, we compared the amounts of MCT1 …

Since its first documented observation in exhausted animal muscle in the early 19th century,
the role of lactate (lactic acid) has fascinated muscle physiologists and biochemists. Initial …

It is now known that lactate traverses the plasma membrane of many tissues, including heart
and muscle, via a stereo-specific, pH-dependent monocarboxylate transport (MCT) system …