The amide bond represents the most fundamental functional group in numerous areas of
chemistry, such as organic synthesis, drug discovery, polymers, and biochemistry. Although …

Abstract Carbon–carbon (C–C) bonds make up the skeletons of most organic molecules.
The selective manipulation of C–C bonds offers a direct approach to editing molecular …

We report the use of photocatalysis for the homolytic ring-opening of carbonyl
cyclopropanes. In contrast to previous studies, our approach does not require a metal …

Fully automated synthetic chemistry would substantially change the field by providing broad
on-demand access to small molecules. However, the reactions that can be run …

Abstract Development of catalytic amide bond-forming methods is important because they
could potentially address the existing limitations of classical methods using …

The direct mechanochemical amidation of esters by ball milling is described. The
operationally simple procedure requires an ester, an amine, and substoichiometric KOtBu …

The challenging transamidation of unactivated tertiary amides has been accomplished via
cooperative acid/iodide catalysis. Most crucially, the method provides a novel manifold to re …

The amide bond N− C activation represents a powerful strategy in organic synthesis to
functionalize the historically inert amide linkage. This personal account highlights recent …

Amide bond construction has garnered significant interest in recent decades due to amides
being one of the most prevalent functional groups among bioactive molecules. Out of the …

The prevalence of amides in biological systems and chemical fields such as polymers,
materials and natural products drives continuous research on novel procedures to obtain …