Quantitative magnetic resonance imaging (qMRI) goes beyond conventional MRI, which
aims primarily at local image contrast. It provides specific physical parameters related to the …

Quantitative MRI provides biophysical measures of the microstructural integrity of the CNS,
which can be compared across CNS regions, patients, and centres. In patients with multiple …

Abstract The Developing Human Connectome Project (dHCP) seeks to create the first 4-
dimensional connectome of early life. Understanding this connectome in detail may provide …

Several MRI measures have been proposed as in vivo biomarkers of myelin, each with
applications ranging from plasticity to pathology. Despite the availability of these myelin …

White matter makes up about fifty percent of the human brain. Maturation of white matter
accompanies biological development and undergoes the most dramatic changes during …

Leukodystrophies comprise a large group of rare genetic disorders primarily affecting CNS
white matter. Historically, the diagnostic process was slow and patient prognosis regarded …

Objectives Currently, multiple sclerosis is treated with anti-inflammatory therapies, but these
treatments lack efficacy in progressive disease. New treatment strategies aim to repair …

White matter deterioration is associated with cognitive impairment in healthy aging and
Alzheimer's disease. It is critical to identify interventions that can slow down white matter …

Obtaining a histological fingerprint from the in-vivo brain has been a long-standing target of
magnetic resonance imaging (MRI). In particular, non-invasive imaging of iron and myelin …

Myelin repair is an unrealized therapeutic goal in the treatment of multiple sclerosis (MS).
Uncertainty remains about the optimal techniques for assessing therapeutic efficacy and …