Computational tools for modern vaccine development

Sunita, A Sajid, Y Singh, P Shukla - Human vaccines & …, 2020 - Taylor & Francis
Vaccines play an essential role in controlling the rates of fatality and morbidity. Vaccines not
only arrest the beginning of different diseases but also assign a gateway for its elimination …

Vaccinomics: A future avenue for vaccine development against emerging pathogens

J de la Fuente, M Contreras - Expert Review of Vaccines, 2021 - Taylor & Francis
Introduction Vaccines are a major achievement in medical sciences, but the development of
more effective vaccines against infectious diseases is essential for prevention and control of …

Designing of a multi-epitope vaccine against the structural proteins of marburg virus exploiting the immunoinformatics approach

SA Sami, KKS Marma, S Mahmud, MAN Khan… - ACS …, 2021 - ACS Publications
Marburg virus disease (MVD) caused by the Marburg virus (MARV) generally appears with
flu-like symptoms and leads to severe hemorrhagic fever. It spreads via direct contact with …

Vaccinomics-based next-generation multi-epitope chimeric vaccine models prediction against Leishmania tropica - a hierarchical subtractive proteomics and …

S Aiman, A Ahmad, AA Khan, AM Alanazi… - Frontiers in …, 2023 - frontiersin.org
Leishmania tropica is a vector-borne parasitic protozoa that is the leading cause of
leishmaniasis throughout the global tropics and subtropics. L. tropica is a multidrug-resistant …

Marburg virus re-emerged in 2022: recently detected in Ghana, another zoonotic pathogen coming up amid rising cases of Monkeypox and ongoing COVID-19 …

R Sah, A Mohanty, A Reda, A Siddiq… - Veterinary …, 2022 - Taylor & Francis
Marburg virus (MARV), a highly pathogenic virus, the cause of a deadly disease Marburg
virus disease (MVD), has recently been in news during mid of July 2022 owing to its …

In silico designing of a multi-epitope vaccine against Burkholderia pseudomallei: Reverse vaccinology and immunoinformatics

M Shahab, C Hayat, R Sikandar, G Zheng… - Journal of Genetic …, 2022 - Elsevier
Background Burkholderia pseudomallei is an infectious agent causing severe disease
melioidosis resulting in pneumonia, fever, and acute septicemia in humans. B. pseudomallei …

In Silico Designing of a Multitope Vaccine against Rhizopus microsporus with Potential Activity against Other Mucormycosis Causing Fungi

MA Soltan, MA Eldeen, N Elbassiouny, HL Kamel… - Cells, 2021 - mdpi.com
During the current era of the COVID-19 pandemic, the dissemination of Mucorales has been
reported globally, with elevated rates of infection in India, and because of the high rate of …

Integrated bioinformatics-based subtractive genomics approach to decipher the therapeutic drug target and its possible intervention against brucellosis

K Khan, MSO Alhar, MN Abbas, SQ Abbas, M Kazi… - Bioengineering, 2022 - mdpi.com
Brucella suis, one of the causative agents of brucellosis, is Gram-negative intracellular
bacteria that may be found all over the globe and it is a significant facultative zoonotic …

Contriving a chimeric polyvalent vaccine to prevent infections caused by herpes simplex virus (type-1 and type-2): an exploratory immunoinformatic approach

M Hasan, S Islam, S Chakraborty… - Journal of …, 2020 - Taylor & Francis
Herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) cause a variety of infections including
oral-facial infections, genital herpes, herpes keratitis, cutaneous infection and so on. To …

Vaccinomics-aided next-generation novel multi-epitope-based vaccine engineering against multidrug resistant Shigella Sonnei: Immunoinformatics and …

S Aiman, A Ahmad, A Khan, Y Ali, A Malik, M Alkholief… - Plos one, 2023 - journals.plos.org
Shigella sonnei is a gram-negative bacterium and is the primary cause of shigellosis in
advanced countries. An exceptional rise in the prevalence of the disease has been reported …