The reprogramming of somatic cells with defined factors, which converts cells from one
lineage into cells of another, has greatly reshaped our traditional views on cell identity and …

Ischemic cell death during a myocardial infarction leads to a multiphase reparative response
in which the damaged tissue is replaced with a fibrotic scar produced by fibroblasts and …

Ischaemic heart disease is a leading cause of death worldwide. Injury to the heart is
followed by loss of the damaged cardiomyocytes, which are replaced with fibrotic scar …

Cellular reprogramming technology has created new opportunities in understanding human
disease, drug discovery, and regenerative medicine. While a combinatorial code was …

Direct lineage conversion offers a new strategy for tissue regeneration and disease
modelling. Despite recent success in directly reprogramming fibroblasts into various cell …

Background: Reprogramming of cardiac fibroblasts into induced cardiomyocyte-like cells in
situ represents a promising strategy for cardiac regeneration. A combination of 3 cardiac …

The methods for the culture and cardiomyocyte differentiation of human embryonic stem
cells, and later human induced pluripotent stem cells (hiPSC), have moved from a complex …

Carbon nanotubes (CNTs), with unique graphitic structure, superior mechanical, electrical,
optical and biological properties, has attracted more and more interests in biomedical …

Direct cardiac reprogramming holds great promise for regenerative medicine. We previously
generated directly reprogrammed induced cardiomyocyte-like cells (iCMs) by …

Adult stem/progenitor are a small population of cells that reside in tissue-specific niches and
possess the potential to differentiate in all cell types of the organ in which they operate. Adult …