Liver and intestine are tightly linked through the venous system of the portal circulation.
Consequently, the liver is the primary recipient of gut-derived products, most prominently …

V-set and immunoglobulin domain containing 4 (VSIG4), a type I transmembrane receptor
exclusively expressed in a subset of tissue-resident macrophages, plays a pivotal role in …

Inhibition of immunocyte infiltration and activation has been suggested to effectively
ameliorate nonalcoholic steatohepatitis (NASH). Paired immunoglobulin-like receptor B …

Background & aims Alcohol use disorder (AUD) represents the most common cause of liver
disease. The gut microbiota plays a critical role in the progression of alcoholrelated liver …

The dissemination of pathogens through blood and their establishment within organs lead to
severe clinical outcomes. However, the within-host dynamics that underlie pathogen spread …

In recent years, steady progress has been made in synthesizing and characterizing
engineered nanoparticles, resulting in several approved drugs and multiple promising …

Sepsis is a lethal systemic inflammatory disease against infection that lacks effective
therapeutic approaches. Liver resident macrophage Kupffer cell (KC)-initiated bacterial …

Many viruses utilize the lymphohematogenous route for dissemination; however, they may
not freely use this highway unchecked. The reticuloendothelial system (RES) is an innate …

abstract Background: Nonalcoholic fatty liver disease (NAFLD) is an independent risk factor
for severe acute pancreatitis (AP). The underlying mechanism remains unclear. We sought …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19.
Until now, diverse drugs have been used for the treatment of COVID-19. These drugs are …