Ever since the “great oxidation event,” Earth's cellular life forms had to cope with the danger
of reactive oxygen species (ROS) affecting the integrity of biomolecules and hampering …

Bacteria encounter a myriad of stresses in their natural environments, including, for
pathogens, their hosts. These stresses elicit a variety of specific and highly regulated …

Pancreatic cancer is a deadly malignancy that lacks effective therapeutics. We previously
reported that oncogenic Kras induced the redox master regulator Nfe2l2/Nrf2 to stimulate …

Hydrogen sulfide-mediated signaling pathways regulate many physiological and
pathophysiological processes in mammalian and plant systems. The molecular mechanism …

Aerobic life requires organisms to resist the damaging effects of ROS (reactive oxygen
species), particularly during stress. Extensive research has established a detailed picture of …

Composed of up to 1,000 phospho-anhydride bond-linked phosphate monomers, inorganic
polyphosphate (polyP) is one of the most ancient, conserved, and enigmatic molecules in …

The Logic of Chance offers a reappraisal and a new synthesis of theories, concepts, and
hypotheses on the key aspects of the evolution of life on earth in light of comparative …

Soybean is an important crop that is continually threatened by abiotic stresses, especially
drought and heat stress. At molecular levels, reduced yields due to drought and heat stress …

Faithful translation of mRNA into the corresponding polypeptide is a complex multistep
process, requiring accurate amino acid selection, transfer RNA (tRNA) charging and mRNA …

DNA damage is frequently encountered in spermatozoa of subfertile males and is correlated
with a range of adverse clinical outcomes including impaired fertilization, disrupted …