Genome-wide CRISPR screens define determinants of epithelial-mesenchymal transition mediated immune evasion by pancreatic cancer cells
The genetic circuits that allow cancer cells to evade immune killing via epithelial
mesenchymal plasticity remain poorly understood. Here, we showed that mesenchymal-like …
mesenchymal plasticity remain poorly understood. Here, we showed that mesenchymal-like …
CD44 acts as a coreceptor for cell-specific enhancement of signaling and regulatory T cell induction by TGM1, a parasite TGF-β mimic
M van Dinther, KT Cunningham… - Proceedings of the …, 2023 - National Acad Sciences
Long-lived parasites evade host immunity through highly evolved molecular strategies. The
murine intestinal helminth, Heligmosomoides polygyrus, down-modulates the host immune …
murine intestinal helminth, Heligmosomoides polygyrus, down-modulates the host immune …
The lncRNA LETS1 promotes TGF-β–induced EMT and cancer cell migration by transcriptionally activating a TβR1-stabilizing mechanism
C Fan, R González-Prieto, TB Kuipers… - Science …, 2023 - science.org
Transforming growth factor–β (TGF-β) signaling is a critical driver of epithelial-to-
mesenchymal transition (EMT) and cancer progression. In SMAD-dependent TGF-β …
mesenchymal transition (EMT) and cancer progression. In SMAD-dependent TGF-β …
Volume imaging to interrogate cancer cell-tumor microenvironment interactions in space and time
Volume imaging visualizes the three-dimensional (3D) complexity of tumors to unravel the
dynamic crosstalk between cancer cells and the heterogeneous landscape of the tumor …
dynamic crosstalk between cancer cells and the heterogeneous landscape of the tumor …
Interstitial flow potentiates TGF-β/Smad-signaling activity in lung cancer spheroids in a 3D-microfluidic chip
Within the tumor microenvironment (TME), cancer cells use mechanotransduction pathways
to convert biophysical forces to biochemical signals. However, the underlying mechanisms …
to convert biophysical forces to biochemical signals. However, the underlying mechanisms …
Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function
EP Carter, KK Yoneten, N Gavara… - The Journal of …, 2024 - Wiley Online Library
Crosstalk between cancer and stellate cells is pivotal in pancreatic cancer, resulting in
differentiation of stellate cells into myofibroblasts that drives tumour progression. To assess …
differentiation of stellate cells into myofibroblasts that drives tumour progression. To assess …
TGM6, a helminth secretory product, mimics TGF-β binding to TβRII to antagonize TGF-β signaling in fibroblasts
SE White, TA Schwartze, A Mukundan, C Schoenherr… - bioRxiv, 2023 - biorxiv.org
The murine helminth parasite Heligmosomoides polygyrus expresses a family of proteins
structurally related to TGF-β Mimic 1 (TGM1), a secreted five domain protein that activates …
structurally related to TGF-β Mimic 1 (TGM1), a secreted five domain protein that activates …
Novel high throughput 3D ECM remodeling assay identifies MEK as key driver of fibrotic fibroblast activity
C Liao, JHM Hundscheid, J Crawford, P ten Dijke… - bioRxiv, 2024 - biorxiv.org
In fibrotic tissues, activated fibroblasts remodel the collagen-rich extracellular matrix (ECM).
Intervening with this process represents a candidate therapeutic strategy to attenuate …
Intervening with this process represents a candidate therapeutic strategy to attenuate …
Innovative Platforms for Macrophage Behavior: Establishment of Stable Macrophage Reporters and Macrophage-Incorporated Airway Organoid
S Zheng - 2024 - search.proquest.com
Macrophages are an essential cellular component of innate immunity that perform
immunosurveillance and maintain tissue homeostasis by detecting the presence of foreign …
immunosurveillance and maintain tissue homeostasis by detecting the presence of foreign …