Most patients with advanced malignancies are treated with severely toxic, first-line
chemotherapies. Personalized treatment strategies have led to improved patient outcomes …

The microenvironment of hematologic cancers contributes to tumor cell survival and
proliferation, as well as treatment resistance. Understanding tumor-and drug-induced …

The microenvironment of chronic lymphocytic leukemia (CLL) cells in lymph nodes, spleen,
and bone marrow provides survival, proliferation, and drug resistance signals. Therapies …

The principle of drug sensitivity testing is to expose cancer cells to a library of different drugs
and measure its effects on cell viability. Recent technological advances, continuous …

Simple Summary Selecting and developing effective therapies for distinct epithelial ovarian
cancer subtypes necessitates tumor models that accurately recapitulate the individual …

The feasibility of a short-term, three-dimensional (3D) culture–based drug sensitivity test
(DST) for surgically resected malignant bone tumors, including osteosarcoma (OS), was …

The tumor microenvironment increases the growth and invasion of cancer cells, makes
classical chemotherapy applications inadequate, and is associated with a poor cancer …

For most types of cancer, the best-known treatments involve combination therapy, and new
therapies are often approved for use in combination. Trials of drug combinations can assess …

The NSC-34 cell line is a widely recognized motor neuron model and various neuronal
differentiation protocols have been exploited. Under previously reported experimental …

Background: Lung organoids have emerged as a promising tool for studying lung
development, function, and disease pathology. The present study aimed to analyze the …