Bioactive compounds in oxidative stress-mediated diseases: targeting the NRF2/ARE signaling pathway and epigenetic regulation

M Thiruvengadam, B Venkidasamy, U Subramanian… - Antioxidants, 2021 - mdpi.com
Oxidative stress is a pathological condition occurring due to an imbalance between the
oxidants and antioxidant defense systems in the body. Nuclear factor E2-related factor 2 …

Rutin ameliorates inflammation and improves metabolic function: A comprehensive analysis of scientific literature

N Muvhulawa, PV Dludla, K Ziqubu… - Pharmacological …, 2022 - Elsevier
Chronic inflammation remains an essential complication in the pathogenesis and
aggravation of metabolic diseases. There is a growing interest in the use of medicinal plants …

Oxidative stress and microvascular alterations in diabetic retinopathy: future therapies

ML Rodríguez, S Pérez, S Mena-Mollá… - Oxidative Medicine …, 2019 - Wiley Online Library
Diabetes is a disease that can be treated with oral antidiabetic agents and/or insulin.
However, patients' metabolic control is inadequate in a high percentage of them and a major …

Protective effect of vanillic acid against diabetes and diabetic nephropathy by attenuating oxidative stress and upregulation of NF‐κB, TNF‐α and COX‐2 proteins in …

B Singh, A Kumar, H Singh, S Kaur… - Phytotherapy …, 2022 - Wiley Online Library
Diabetes is the most prevalent disorder in the world characterized by uncontrolled high
blood glucose levels and nephropathy is one of the chief complications allied with …

Dehydroabietic acid improves nonalcoholic fatty liver disease through activating the Keap1/Nrf2-ARE signaling pathway to reduce ferroptosis

G Gao, Z Xie, E Li, Y Yuan, Y Fu, P Wang… - Journal of natural …, 2021 - Springer
The accumulation of iron-dependent lipid peroxides is one of the important causes of
NAFLD. The purpose of this study is to explore the effect of dehydroabietic acid (DA) on …

[HTML][HTML] Nrf2 signaling in diabetic nephropathy, cardiomyopathy and neuropathy: therapeutic targeting, challenges and future prospective

M Hashemi, MA Zandieh, S Ziaolhagh… - … et Biophysica Acta (BBA …, 2023 - Elsevier
Western lifestyle contributes to an overt increase in the prevalence of metabolic anomalies
including diabetes mellitus (DM) and obesity. Prevalence of DM is rapidly growing …

Lithium co-administration with rutin improves post-stroke neurological outcomes via suppressing Gsk-3β activity in a rat model

AK Rana, R Kumar, DN Shukla, D Singh - Free Radical Biology and …, 2023 - Elsevier
Cerebral ischemic stroke is one of the leading causes of adult disability worldwide.
Reperfusion is the only therapeutic option with a lot of side effects. In the current study, we …

Antioxidant phytochemicals as potential therapy for diabetic complications

OOP Akpoveso, EE Ubah, G Obasanmi - Antioxidants, 2023 - mdpi.com
The global prevalence of diabetes continues to increase partly due to rapid urbanization and
an increase in the aging population. Consequently, this is associated with a parallel …

[HTML][HTML] Protective effect of quercetin on streptozotocin-induced diabetic peripheral neuropathy rats through modulating gut microbiota and reactive oxygen species …

J Xie, W Song, X Liang, Q Zhang, Y Shi, W Liu… - Biomedicine & …, 2020 - Elsevier
Highlights•Quercetin significantly ameliorated the phenotypes and decreased the ROS
production levels in DPN rats.•Quercetin was firstly found to modulate gut microbiota in DPN …

Rutin and selenium nanoparticles protected against STZ-induced diabetic nephropathy in rats through downregulating Jak-2/Stat3 pathway and upregulating Nrf-2/HO …

RA Zaghloul, AM Abdelghany, YA Samra - European Journal of …, 2022 - Elsevier
Diabetic nephropathy (DN) is a renal complication of diabetic hyperglycemia. The Signal
transducer and activator of transcription 3 (Stat3) is a center molecule of the chronic …