Insulin action in brain regulates systemic metabolism and brain function

A Kleinridders, HA Ferris, W Cai, CR Kahn - Diabetes, 2014 - Am Diabetes Assoc
Insulin receptors, as well as IGF-1 receptors and their postreceptor signaling partners, are
distributed throughout the brain. Insulin acts on these receptors to modulate peripheral …

Cognitive function in patients with diabetes mellitus: guidance for daily care

PS Koekkoek, LJ Kappelle, E van den Berg… - The Lancet …, 2015 - thelancet.com
Diabetes mellitus is associated with an increase in the risk of dementia and the proportion of
patients who convert from mild cognitive impairment (MCI) to dementia. In addition to MCI …

[HTML][HTML] A systematic review of preclinical studies exploring the role of insulin signalling in executive function and memory

AM Ottomana, M Presta, A O'Leary, M Sullivan… - … & biobehavioral reviews, 2023 - Elsevier
Beside its involvement in somatic dysfunctions, altered insulin signalling constitutes a risk
factor for the development of mental disorders like Alzheimer's disease and obsessive …

[PDF][PDF] Diabetic central neuropathy: CNS damage related to hyperglycemia

JI Malone - Diabetes, 2016 - researchgate.net
Diabetes is a syndrome defined by higher than normal blood glucose levels. Those higher
blood glucose levels are associated with the development of physical abnormalities termed …

Brain structure among middle-aged and older adults with long-standing type 1 diabetes in the DCCT/EDIC study

AM Jacobson, BH Braffett, G Erus, CM Ryan… - Diabetes …, 2022 - Am Diabetes Assoc
OBJECTIVE Individuals with type 1 diabetes mellitus (T1DM) are living to ages when
neuropathological changes are increasingly evident. We hypothesized that middle-aged …

Acute hyperglycaemia leads to altered frontal lobe brain activity and reduced working memory in type 2 diabetes

A Backeström, K Papadopoulos, S Eriksson, T Olsson… - PLoS …, 2021 - journals.plos.org
How acute hyperglycaemia affects memory functions and functional brain responses in
individuals with and without type 2 diabetes is unclear. Our aim was to study the association …

Altered integration of structural covariance networks in young children with type 1 diabetes

SMH Hosseini, P Mazaika, N Mauras… - Human brain …, 2016 - Wiley Online Library
Type 1 diabetes mellitus (T1D), one of the most frequent chronic diseases in children, is
associated with glucose dysregulation that contributes to an increased risk for …

Central nervous system microstructural alterations in type 1 diabetes mellitus: a systematic review of diffusion tensor imaging studies

M Dolatshahi, HS Moghaddam, P Saberi… - Diabetes Research and …, 2023 - Elsevier
Aims Type 1 diabetes mellitus (T1DM) is a chronic childhood disease with potentially
persistent CNS disruptions. In this study, we aimed to systematically review diffusion tensor …

[HTML][HTML] Decreased spontaneous brain activity and functional connectivity in type 1 diabetic patients without microvascular complications

W Xia, YC Chen, Y Luo, DF Zhang, H Chen… - Cellular Physiology and …, 2019 - karger.com
Background/Aims: Type 1 diabetes mellitus (T1DM) has been proven to be associated with
an increased risk of cognitive dysfunction. In this study, we aimed to investigate whether …

Disrupted subject‐specific gray matter network properties and cognitive dysfunction in type 1 diabetes patients with and without proliferative retinopathy

E van Duinkerken, RG Ijzerman, M Klein… - Human brain …, 2016 - Wiley Online Library
Introduction Type 1 diabetes mellitus (T1DM) patients, especially with concomitant
microvascular disease, such as proliferative retinopathy, have an increased risk of cognitive …