[HTML][HTML] De novo biosynthesis of berberine and halogenated benzylisoquinoline alkaloids in Saccharomyces cerevisiae
Berberine is an extensively used pharmaceutical benzylisoquinoline alkaloid (BIA) derived
from plants. Microbial manufacturing has emerged as a promising approach to source …
from plants. Microbial manufacturing has emerged as a promising approach to source …
Leveraging yeast to characterize plant biosynthetic gene clusters
Y Wu, FL Gong, S Li - Current opinion in plant biology, 2023 - Elsevier
Plant biosynthetic gene clusters (BGCs) contain multiple physically clustered non-
homologous genes that encode enzymes catalyzing diverse reactions in one plant natural …
homologous genes that encode enzymes catalyzing diverse reactions in one plant natural …
Enabling pathway design by multiplex experimentation and machine learning
AG Boob, J Chen, H Zhao - Metabolic Engineering, 2024 - Elsevier
The remarkable metabolic diversity observed in nature has provided a foundation for
sustainable production of a wide array of valuable molecules. However, transferring the …
sustainable production of a wide array of valuable molecules. However, transferring the …
[HTML][HTML] Engineered biosynthesis of plant polyketides by type III polyketide synthases in microorganisms
C Liu, S Li - Frontiers in Bioengineering and Biotechnology, 2022 - frontiersin.org
Plant specialized metabolites occupy unique therapeutic niches in human medicine. A large
family of plant specialized metabolites, namely plant polyketides, exhibit diverse and …
family of plant specialized metabolites, namely plant polyketides, exhibit diverse and …
The application of gene-editing technologies in the biosynthesis of plant-derived bioactive compounds
X Sun, M Li, Y Mei, M Jia - … Biology for Microbial Biosynthesis of Plant …, 2024 - Elsevier
Gene-editing technologies represented by the classical clustered regularly interspaced short
palindromic repeats (CRISPR)-Cas9 system have been widely used in large DNA fragment …
palindromic repeats (CRISPR)-Cas9 system have been widely used in large DNA fragment …
DNA assembly techniques for the reconstitution of plant natural product biosynthetic pathways in Saccharomyces cerevisiae
J Lian - Engineering Biology for Microbial Biosynthesis of Plant …, 2024 - Elsevier
Plant natural products are a diverse and important group of compounds with numerous
applications in medicine, agriculture, and industry. There is a growing interest in producing …
applications in medicine, agriculture, and industry. There is a growing interest in producing …