Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism
I Elia, MC Haigis - Nature metabolism, 2021 - nature.com
Metabolic transformation is a hallmark of cancer and a critical target for cancer therapy.
Cancer metabolism and behaviour are regulated by cell-intrinsic factors as well as …
Cancer metabolism and behaviour are regulated by cell-intrinsic factors as well as …
PGC-1α is a master regulator of mitochondrial lifecycle and ROS stress response
Mitochondria play a major role in ROS production and defense during their life cycle. The
transcriptional activator PGC-1α is a key player in the homeostasis of energy metabolism …
transcriptional activator PGC-1α is a key player in the homeostasis of energy metabolism …
ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for
coronavirus disease 2019 (COVID-19), continues to cause substantial morbidity and …
coronavirus disease 2019 (COVID-19), continues to cause substantial morbidity and …
[HTML][HTML] Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context
M Morgenstern, CD Peikert, P Lübbert, I Suppanz… - Cell metabolism, 2021 - cell.com
Mitochondria are key organelles for cellular energetics, metabolism, signaling, and quality
control and have been linked to various diseases. Different views exist on the composition of …
control and have been linked to various diseases. Different views exist on the composition of …
The functional impact of mitochondrial structure across subcellular scales
Mitochondria are key determinants of cellular health. However, the functional role of
mitochondria varies from cell to cell depending on the relative demands for energy …
mitochondria varies from cell to cell depending on the relative demands for energy …
Biomarkers of oxidative stress in metabolic syndrome and associated diseases
R Vona, L Gambardella, C Cittadini… - Oxidative medicine …, 2019 - Wiley Online Library
Metabolic syndrome (MS) represents worldwide public health issue characterized by a set of
cardiovascular risk factors including obesity, diabetes, dyslipidemia, hypertension, and …
cardiovascular risk factors including obesity, diabetes, dyslipidemia, hypertension, and …
Crosstalk between mitochondrial dysfunction, oxidative stress, and age related neurodegenerative disease: Etiologies and therapeutic strategies
Mitochondrial function is vital for normal cellular processes. Mitochondrial damage and
oxidative stress have been greatly implicated in the progression of aging, along with the …
oxidative stress have been greatly implicated in the progression of aging, along with the …
Definition of a high-confidence mitochondrial proteome at quantitative scale
M Morgenstern, SB Stiller, P Lübbert, CD Peikert… - Cell reports, 2017 - cell.com
Mitochondria perform central functions in cellular bioenergetics, metabolism, and signaling,
and their dysfunction has been linked to numerous diseases. The available studies cover …
and their dysfunction has been linked to numerous diseases. The available studies cover …
Control of osteoblast regeneration by a train of Erk activity waves
A De Simone, MN Evanitsky, L Hayden, BD Cox… - Nature, 2021 - nature.com
Regeneration is a complex chain of events that restores a tissue to its original size and
shape. The tissue-wide coordination of cellular dynamics that is needed for proper …
shape. The tissue-wide coordination of cellular dynamics that is needed for proper …
Ethanolamine and phosphatidylethanolamine: partners in health and disease
Phosphatidylethanolamine (PE) is the second most abundant phospholipid in mammalian
cells. PE comprises about 15–25% of the total lipid in mammalian cells; it is enriched in the …
cells. PE comprises about 15–25% of the total lipid in mammalian cells; it is enriched in the …